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Particle Therapy: Clinical Applications and Biological Effects

Particle therapy is a developing area of radiotherapy, mostly involving the use of protons, neutrons and carbon ions for cancer treatment. The reduction of side effects on healthy tissues in the peritumoral area is an important advantage of particle therapy. In this review, we analyze state-of-the-a...

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Autores principales: Kiseleva, Viktoriia, Gordon, Konstantin, Vishnyakova, Polina, Gantsova, Elena, Elchaninov, Andrey, Fatkhudinov, Timur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785772/
https://www.ncbi.nlm.nih.gov/pubmed/36556436
http://dx.doi.org/10.3390/life12122071
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author Kiseleva, Viktoriia
Gordon, Konstantin
Vishnyakova, Polina
Gantsova, Elena
Elchaninov, Andrey
Fatkhudinov, Timur
author_facet Kiseleva, Viktoriia
Gordon, Konstantin
Vishnyakova, Polina
Gantsova, Elena
Elchaninov, Andrey
Fatkhudinov, Timur
author_sort Kiseleva, Viktoriia
collection PubMed
description Particle therapy is a developing area of radiotherapy, mostly involving the use of protons, neutrons and carbon ions for cancer treatment. The reduction of side effects on healthy tissues in the peritumoral area is an important advantage of particle therapy. In this review, we analyze state-of-the-art particle therapy, as compared to conventional photon therapy, to identify clinical benefits and specify the mechanisms of action on tumor cells. Systematization of published data on particle therapy confirms its successful application in a wide range of cancers and reveals a variety of biological effects which manifest at the molecular level and produce the particle therapy-specific molecular signatures. Given the rapid progress in the field, the use of particle therapy holds great promise for the near future.
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spelling pubmed-97857722022-12-24 Particle Therapy: Clinical Applications and Biological Effects Kiseleva, Viktoriia Gordon, Konstantin Vishnyakova, Polina Gantsova, Elena Elchaninov, Andrey Fatkhudinov, Timur Life (Basel) Review Particle therapy is a developing area of radiotherapy, mostly involving the use of protons, neutrons and carbon ions for cancer treatment. The reduction of side effects on healthy tissues in the peritumoral area is an important advantage of particle therapy. In this review, we analyze state-of-the-art particle therapy, as compared to conventional photon therapy, to identify clinical benefits and specify the mechanisms of action on tumor cells. Systematization of published data on particle therapy confirms its successful application in a wide range of cancers and reveals a variety of biological effects which manifest at the molecular level and produce the particle therapy-specific molecular signatures. Given the rapid progress in the field, the use of particle therapy holds great promise for the near future. MDPI 2022-12-09 /pmc/articles/PMC9785772/ /pubmed/36556436 http://dx.doi.org/10.3390/life12122071 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kiseleva, Viktoriia
Gordon, Konstantin
Vishnyakova, Polina
Gantsova, Elena
Elchaninov, Andrey
Fatkhudinov, Timur
Particle Therapy: Clinical Applications and Biological Effects
title Particle Therapy: Clinical Applications and Biological Effects
title_full Particle Therapy: Clinical Applications and Biological Effects
title_fullStr Particle Therapy: Clinical Applications and Biological Effects
title_full_unstemmed Particle Therapy: Clinical Applications and Biological Effects
title_short Particle Therapy: Clinical Applications and Biological Effects
title_sort particle therapy: clinical applications and biological effects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785772/
https://www.ncbi.nlm.nih.gov/pubmed/36556436
http://dx.doi.org/10.3390/life12122071
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