Cargando…
Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review
In most dermatological pathologies, the phenomena observed on the skin are a reflection of internal disorders. In patients with associated acral involvement on the dorsal sides of the hands, this “vitiligo phenotype” may lead to the investigation of certain associated pathologies that sometimes have...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785784/ https://www.ncbi.nlm.nih.gov/pubmed/36556267 http://dx.doi.org/10.3390/jpm12122048 |
_version_ | 1784858132972830720 |
---|---|
author | Chivu, Ana Maria Bălășescu, Elena Pandia, Larisa Diana Nedelcu, Roxana Ioana Brînzea, Alice Turcu, Gabriela Antohe, Mihaela Ion, Daniela Adriana |
author_facet | Chivu, Ana Maria Bălășescu, Elena Pandia, Larisa Diana Nedelcu, Roxana Ioana Brînzea, Alice Turcu, Gabriela Antohe, Mihaela Ion, Daniela Adriana |
author_sort | Chivu, Ana Maria |
collection | PubMed |
description | In most dermatological pathologies, the phenomena observed on the skin are a reflection of internal disorders. In patients with associated acral involvement on the dorsal sides of the hands, this “vitiligo phenotype” may lead to the investigation of certain associated pathologies that sometimes have no obvious clinical impact. To assess the link between skin depigmentation and autoimmune pathologies, we conducted a systematic review involving article selection from the PubMed database. Patients with coexisting thyroid pathologies were found to have a predisposition for developing acral vitiligo and depigmentation of the wrists, and autoimmune thyroid pathologies appeared to be the only coexisting autoimmune or inflammatory diseases in vitiligo patients to show a pattern of distribution. The association of concomitant thyroid dysfunction with depigmentation of the hands was found to be so strong that the absence of depigmented macules on the hands may exclude the coexistence of an autoimmune thyroid pathology. Although the frequency of acral involvement in patients with vitiligo and autoimmune pathologies is higher, the mechanism by which thyroid dysfunction influences this distribution pattern remains incompletely elucidated and requires future studies. |
format | Online Article Text |
id | pubmed-9785784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97857842022-12-24 Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review Chivu, Ana Maria Bălășescu, Elena Pandia, Larisa Diana Nedelcu, Roxana Ioana Brînzea, Alice Turcu, Gabriela Antohe, Mihaela Ion, Daniela Adriana J Pers Med Review In most dermatological pathologies, the phenomena observed on the skin are a reflection of internal disorders. In patients with associated acral involvement on the dorsal sides of the hands, this “vitiligo phenotype” may lead to the investigation of certain associated pathologies that sometimes have no obvious clinical impact. To assess the link between skin depigmentation and autoimmune pathologies, we conducted a systematic review involving article selection from the PubMed database. Patients with coexisting thyroid pathologies were found to have a predisposition for developing acral vitiligo and depigmentation of the wrists, and autoimmune thyroid pathologies appeared to be the only coexisting autoimmune or inflammatory diseases in vitiligo patients to show a pattern of distribution. The association of concomitant thyroid dysfunction with depigmentation of the hands was found to be so strong that the absence of depigmented macules on the hands may exclude the coexistence of an autoimmune thyroid pathology. Although the frequency of acral involvement in patients with vitiligo and autoimmune pathologies is higher, the mechanism by which thyroid dysfunction influences this distribution pattern remains incompletely elucidated and requires future studies. MDPI 2022-12-12 /pmc/articles/PMC9785784/ /pubmed/36556267 http://dx.doi.org/10.3390/jpm12122048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chivu, Ana Maria Bălășescu, Elena Pandia, Larisa Diana Nedelcu, Roxana Ioana Brînzea, Alice Turcu, Gabriela Antohe, Mihaela Ion, Daniela Adriana Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
title | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
title_full | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
title_fullStr | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
title_full_unstemmed | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
title_short | Vitiligo—Thyroid Disease Association: When, in Whom, and Why Should It Be Suspected? A Systematic Review |
title_sort | vitiligo—thyroid disease association: when, in whom, and why should it be suspected? a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785784/ https://www.ncbi.nlm.nih.gov/pubmed/36556267 http://dx.doi.org/10.3390/jpm12122048 |
work_keys_str_mv | AT chivuanamaria vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview AT balasescuelena vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview AT pandialarisadiana vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview AT nedelcuroxanaioana vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview AT brinzeaalice vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview AT turcugabriela vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview AT antohemihaela vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview AT iondanielaadriana vitiligothyroiddiseaseassociationwheninwhomandwhyshoulditbesuspectedasystematicreview |