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Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level of insulin, plays crucial roles in the development and progression of diabetes, nonalcoholic fatty liver disease (NAFLD) and other diseases. So far, the distinct mechanism(s) of IR still need...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785789/ https://www.ncbi.nlm.nih.gov/pubmed/36555704 http://dx.doi.org/10.3390/ijms232416054 |
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author | Yang, Weili Lyu, Yixiang Xiang, Rui Yang, Jichun |
author_facet | Yang, Weili Lyu, Yixiang Xiang, Rui Yang, Jichun |
author_sort | Yang, Weili |
collection | PubMed |
description | Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level of insulin, plays crucial roles in the development and progression of diabetes, nonalcoholic fatty liver disease (NAFLD) and other diseases. So far, the distinct mechanism(s) of IR still needs further exploration. Long non-coding RNA (lncRNA) is a class of non-protein coding RNA molecules with a length greater than 200 nucleotides. LncRNAs are widely involved in many biological processes including cell differentiation, proliferation, apoptosis and metabolism. More recently, there has been increasing evidence that lncRNAs participated in the pathogenesis of IR, and the dysregulated lncRNA profile played important roles in the pathogenesis of metabolic diseases including obesity, diabetes and NAFLD. For example, the lncRNAs MEG3, H19, MALAT1, GAS5, lncSHGL and several other lncRNAs have been shown to regulate insulin signaling and glucose/lipid metabolism in various tissues. In this review, we briefly introduced the general features of lncRNA and the methods for lncRNA research, and then summarized and discussed the recent advances on the roles and mechanisms of lncRNAs in IR, particularly focused on liver, skeletal muscle and adipose tissues. |
format | Online Article Text |
id | pubmed-9785789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97857892022-12-24 Long Noncoding RNAs in the Pathogenesis of Insulin Resistance Yang, Weili Lyu, Yixiang Xiang, Rui Yang, Jichun Int J Mol Sci Review Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level of insulin, plays crucial roles in the development and progression of diabetes, nonalcoholic fatty liver disease (NAFLD) and other diseases. So far, the distinct mechanism(s) of IR still needs further exploration. Long non-coding RNA (lncRNA) is a class of non-protein coding RNA molecules with a length greater than 200 nucleotides. LncRNAs are widely involved in many biological processes including cell differentiation, proliferation, apoptosis and metabolism. More recently, there has been increasing evidence that lncRNAs participated in the pathogenesis of IR, and the dysregulated lncRNA profile played important roles in the pathogenesis of metabolic diseases including obesity, diabetes and NAFLD. For example, the lncRNAs MEG3, H19, MALAT1, GAS5, lncSHGL and several other lncRNAs have been shown to regulate insulin signaling and glucose/lipid metabolism in various tissues. In this review, we briefly introduced the general features of lncRNA and the methods for lncRNA research, and then summarized and discussed the recent advances on the roles and mechanisms of lncRNAs in IR, particularly focused on liver, skeletal muscle and adipose tissues. MDPI 2022-12-16 /pmc/articles/PMC9785789/ /pubmed/36555704 http://dx.doi.org/10.3390/ijms232416054 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yang, Weili Lyu, Yixiang Xiang, Rui Yang, Jichun Long Noncoding RNAs in the Pathogenesis of Insulin Resistance |
title | Long Noncoding RNAs in the Pathogenesis of Insulin Resistance |
title_full | Long Noncoding RNAs in the Pathogenesis of Insulin Resistance |
title_fullStr | Long Noncoding RNAs in the Pathogenesis of Insulin Resistance |
title_full_unstemmed | Long Noncoding RNAs in the Pathogenesis of Insulin Resistance |
title_short | Long Noncoding RNAs in the Pathogenesis of Insulin Resistance |
title_sort | long noncoding rnas in the pathogenesis of insulin resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785789/ https://www.ncbi.nlm.nih.gov/pubmed/36555704 http://dx.doi.org/10.3390/ijms232416054 |
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