Cargando…

Long Noncoding RNAs in the Pathogenesis of Insulin Resistance

Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level of insulin, plays crucial roles in the development and progression of diabetes, nonalcoholic fatty liver disease (NAFLD) and other diseases. So far, the distinct mechanism(s) of IR still need...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Weili, Lyu, Yixiang, Xiang, Rui, Yang, Jichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785789/
https://www.ncbi.nlm.nih.gov/pubmed/36555704
http://dx.doi.org/10.3390/ijms232416054
_version_ 1784858134184984576
author Yang, Weili
Lyu, Yixiang
Xiang, Rui
Yang, Jichun
author_facet Yang, Weili
Lyu, Yixiang
Xiang, Rui
Yang, Jichun
author_sort Yang, Weili
collection PubMed
description Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level of insulin, plays crucial roles in the development and progression of diabetes, nonalcoholic fatty liver disease (NAFLD) and other diseases. So far, the distinct mechanism(s) of IR still needs further exploration. Long non-coding RNA (lncRNA) is a class of non-protein coding RNA molecules with a length greater than 200 nucleotides. LncRNAs are widely involved in many biological processes including cell differentiation, proliferation, apoptosis and metabolism. More recently, there has been increasing evidence that lncRNAs participated in the pathogenesis of IR, and the dysregulated lncRNA profile played important roles in the pathogenesis of metabolic diseases including obesity, diabetes and NAFLD. For example, the lncRNAs MEG3, H19, MALAT1, GAS5, lncSHGL and several other lncRNAs have been shown to regulate insulin signaling and glucose/lipid metabolism in various tissues. In this review, we briefly introduced the general features of lncRNA and the methods for lncRNA research, and then summarized and discussed the recent advances on the roles and mechanisms of lncRNAs in IR, particularly focused on liver, skeletal muscle and adipose tissues.
format Online
Article
Text
id pubmed-9785789
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97857892022-12-24 Long Noncoding RNAs in the Pathogenesis of Insulin Resistance Yang, Weili Lyu, Yixiang Xiang, Rui Yang, Jichun Int J Mol Sci Review Insulin resistance (IR), designated as the blunted response of insulin target tissues to physiological level of insulin, plays crucial roles in the development and progression of diabetes, nonalcoholic fatty liver disease (NAFLD) and other diseases. So far, the distinct mechanism(s) of IR still needs further exploration. Long non-coding RNA (lncRNA) is a class of non-protein coding RNA molecules with a length greater than 200 nucleotides. LncRNAs are widely involved in many biological processes including cell differentiation, proliferation, apoptosis and metabolism. More recently, there has been increasing evidence that lncRNAs participated in the pathogenesis of IR, and the dysregulated lncRNA profile played important roles in the pathogenesis of metabolic diseases including obesity, diabetes and NAFLD. For example, the lncRNAs MEG3, H19, MALAT1, GAS5, lncSHGL and several other lncRNAs have been shown to regulate insulin signaling and glucose/lipid metabolism in various tissues. In this review, we briefly introduced the general features of lncRNA and the methods for lncRNA research, and then summarized and discussed the recent advances on the roles and mechanisms of lncRNAs in IR, particularly focused on liver, skeletal muscle and adipose tissues. MDPI 2022-12-16 /pmc/articles/PMC9785789/ /pubmed/36555704 http://dx.doi.org/10.3390/ijms232416054 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Weili
Lyu, Yixiang
Xiang, Rui
Yang, Jichun
Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
title Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
title_full Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
title_fullStr Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
title_full_unstemmed Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
title_short Long Noncoding RNAs in the Pathogenesis of Insulin Resistance
title_sort long noncoding rnas in the pathogenesis of insulin resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785789/
https://www.ncbi.nlm.nih.gov/pubmed/36555704
http://dx.doi.org/10.3390/ijms232416054
work_keys_str_mv AT yangweili longnoncodingrnasinthepathogenesisofinsulinresistance
AT lyuyixiang longnoncodingrnasinthepathogenesisofinsulinresistance
AT xiangrui longnoncodingrnasinthepathogenesisofinsulinresistance
AT yangjichun longnoncodingrnasinthepathogenesisofinsulinresistance