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Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event

Freshwater mussels (Unionida) are among the world’s most imperiled taxa, but the relationship between freshwater mussel mortality events and infectious disease is largely unstudied. We surveyed viromes of a widespread and abundant species (mucket, Actinonaias ligamentina; syn: Ortmanniana ligamentin...

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Autores principales: Richard, Jordan C., Leis, Eric M., Dunn, Christopher D., Harris, Cleyo, Agbalog, Rose E., Campbell, Lewis J., Knowles, Susan, Waller, Diane L., Putnam, Joel G., Goldberg, Tony L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785814/
https://www.ncbi.nlm.nih.gov/pubmed/36560607
http://dx.doi.org/10.3390/v14122603
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author Richard, Jordan C.
Leis, Eric M.
Dunn, Christopher D.
Harris, Cleyo
Agbalog, Rose E.
Campbell, Lewis J.
Knowles, Susan
Waller, Diane L.
Putnam, Joel G.
Goldberg, Tony L.
author_facet Richard, Jordan C.
Leis, Eric M.
Dunn, Christopher D.
Harris, Cleyo
Agbalog, Rose E.
Campbell, Lewis J.
Knowles, Susan
Waller, Diane L.
Putnam, Joel G.
Goldberg, Tony L.
author_sort Richard, Jordan C.
collection PubMed
description Freshwater mussels (Unionida) are among the world’s most imperiled taxa, but the relationship between freshwater mussel mortality events and infectious disease is largely unstudied. We surveyed viromes of a widespread and abundant species (mucket, Actinonaias ligamentina; syn: Ortmanniana ligamentina) experiencing a mortality event of unknown etiology in the Huron River, Michigan, in 2019–2020 and compared them to viromes from mucket in a healthy population in the St. Croix River, Wisconsin and a population from the Clinch River, Virginia and Tennessee, where a mortality event was affecting the congeneric pheasantshell (Actinonaias pectorosa; syn: Ortmanniana pectorosa) population. We identified 38 viruses, most of which were associated with mussels collected during the Huron River mortality event. Viral richness and cumulative viral read depths were significantly higher in moribund mussels from the Huron River than in healthy controls from each of the three populations. Our results demonstrate significant increases in the number and intensity of viral infections for freshwater mussels experiencing mortality events, whereas individuals from healthy populations have a substantially reduced virome comprising a limited number of species at low viral read depths.
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spelling pubmed-97858142022-12-24 Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event Richard, Jordan C. Leis, Eric M. Dunn, Christopher D. Harris, Cleyo Agbalog, Rose E. Campbell, Lewis J. Knowles, Susan Waller, Diane L. Putnam, Joel G. Goldberg, Tony L. Viruses Article Freshwater mussels (Unionida) are among the world’s most imperiled taxa, but the relationship between freshwater mussel mortality events and infectious disease is largely unstudied. We surveyed viromes of a widespread and abundant species (mucket, Actinonaias ligamentina; syn: Ortmanniana ligamentina) experiencing a mortality event of unknown etiology in the Huron River, Michigan, in 2019–2020 and compared them to viromes from mucket in a healthy population in the St. Croix River, Wisconsin and a population from the Clinch River, Virginia and Tennessee, where a mortality event was affecting the congeneric pheasantshell (Actinonaias pectorosa; syn: Ortmanniana pectorosa) population. We identified 38 viruses, most of which were associated with mussels collected during the Huron River mortality event. Viral richness and cumulative viral read depths were significantly higher in moribund mussels from the Huron River than in healthy controls from each of the three populations. Our results demonstrate significant increases in the number and intensity of viral infections for freshwater mussels experiencing mortality events, whereas individuals from healthy populations have a substantially reduced virome comprising a limited number of species at low viral read depths. MDPI 2022-11-23 /pmc/articles/PMC9785814/ /pubmed/36560607 http://dx.doi.org/10.3390/v14122603 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Richard, Jordan C.
Leis, Eric M.
Dunn, Christopher D.
Harris, Cleyo
Agbalog, Rose E.
Campbell, Lewis J.
Knowles, Susan
Waller, Diane L.
Putnam, Joel G.
Goldberg, Tony L.
Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event
title Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event
title_full Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event
title_fullStr Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event
title_full_unstemmed Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event
title_short Freshwater Mussels Show Elevated Viral Richness and Intensity during a Mortality Event
title_sort freshwater mussels show elevated viral richness and intensity during a mortality event
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785814/
https://www.ncbi.nlm.nih.gov/pubmed/36560607
http://dx.doi.org/10.3390/v14122603
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