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Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort

The association between prenatal phthalate exposure and late preterm birth (LPTB) is unclear. We examined singleton pregnancies (2006–2011) from a racially and socioeconomically diverse sample of women in the CANDLE cohort of the ECHO-PATHWAYS Consortium. Urine collected in the second and third trim...

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Autores principales: Sienas, Laura, Albright, Catherine, Ni, Yu, Szpiro, Adam, Bush, Nicole R., Loftus, Christine, Kannan, Kurunthachalam, Tylavsky, Frances, Karr, Catherine J., LeWinn, Kaja Z., Sathyanarayana, Sheela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785862/
https://www.ncbi.nlm.nih.gov/pubmed/36548587
http://dx.doi.org/10.3390/toxics10120754
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author Sienas, Laura
Albright, Catherine
Ni, Yu
Szpiro, Adam
Bush, Nicole R.
Loftus, Christine
Kannan, Kurunthachalam
Tylavsky, Frances
Karr, Catherine J.
LeWinn, Kaja Z.
Sathyanarayana, Sheela
author_facet Sienas, Laura
Albright, Catherine
Ni, Yu
Szpiro, Adam
Bush, Nicole R.
Loftus, Christine
Kannan, Kurunthachalam
Tylavsky, Frances
Karr, Catherine J.
LeWinn, Kaja Z.
Sathyanarayana, Sheela
author_sort Sienas, Laura
collection PubMed
description The association between prenatal phthalate exposure and late preterm birth (LPTB) is unclear. We examined singleton pregnancies (2006–2011) from a racially and socioeconomically diverse sample of women in the CANDLE cohort of the ECHO-PATHWAYS Consortium. Urine collected in the second and third trimester was analyzed for 14 phthalate metabolites. Multivariate logistic and linear regressions were performed for LPTB, defined as delivery 34–37 weeks, and gestational week, respectively. Models were controlled for socio-demographics, behavioral factors, clinical measurements, medical history, and phthalates in the other trimester. Effect modification by race and pregnancy stress, indicated by intimate partner violence (IPV), was investigated. We conducted a secondary analysis in women with spontaneous preterm labor. The rate of LPTB among 1408 women (61% Black, 32% White) was 6.7%. There was no evidence of decreased gestational age (GA) in association with any phthalate metabolite. Each two-fold increase in third trimester mono-benzyl phthalate (MBzP) was associated with 0.08 weeks longer gestational age (95% CI: 0.03, 0.12). When restricting to women with spontaneous labor, second trimester mono-n-butyl phthalate (MBP) was associated with 54% higher odds (95% CI: 2%, 132%) of LPTB. Associations were not modified by maternal race or IPV exposure. In conclusion, we observed mixed evidence concerning our hypothesis that prenatal phthalate exposure increases risk of LPTB, though secondary analyses suggest increased risk of spontaneous LPTB associated with MBP, which is consistent with a recent pooled analysis of 16 cohorts.
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spelling pubmed-97858622022-12-24 Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort Sienas, Laura Albright, Catherine Ni, Yu Szpiro, Adam Bush, Nicole R. Loftus, Christine Kannan, Kurunthachalam Tylavsky, Frances Karr, Catherine J. LeWinn, Kaja Z. Sathyanarayana, Sheela Toxics Article The association between prenatal phthalate exposure and late preterm birth (LPTB) is unclear. We examined singleton pregnancies (2006–2011) from a racially and socioeconomically diverse sample of women in the CANDLE cohort of the ECHO-PATHWAYS Consortium. Urine collected in the second and third trimester was analyzed for 14 phthalate metabolites. Multivariate logistic and linear regressions were performed for LPTB, defined as delivery 34–37 weeks, and gestational week, respectively. Models were controlled for socio-demographics, behavioral factors, clinical measurements, medical history, and phthalates in the other trimester. Effect modification by race and pregnancy stress, indicated by intimate partner violence (IPV), was investigated. We conducted a secondary analysis in women with spontaneous preterm labor. The rate of LPTB among 1408 women (61% Black, 32% White) was 6.7%. There was no evidence of decreased gestational age (GA) in association with any phthalate metabolite. Each two-fold increase in third trimester mono-benzyl phthalate (MBzP) was associated with 0.08 weeks longer gestational age (95% CI: 0.03, 0.12). When restricting to women with spontaneous labor, second trimester mono-n-butyl phthalate (MBP) was associated with 54% higher odds (95% CI: 2%, 132%) of LPTB. Associations were not modified by maternal race or IPV exposure. In conclusion, we observed mixed evidence concerning our hypothesis that prenatal phthalate exposure increases risk of LPTB, though secondary analyses suggest increased risk of spontaneous LPTB associated with MBP, which is consistent with a recent pooled analysis of 16 cohorts. MDPI 2022-12-03 /pmc/articles/PMC9785862/ /pubmed/36548587 http://dx.doi.org/10.3390/toxics10120754 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sienas, Laura
Albright, Catherine
Ni, Yu
Szpiro, Adam
Bush, Nicole R.
Loftus, Christine
Kannan, Kurunthachalam
Tylavsky, Frances
Karr, Catherine J.
LeWinn, Kaja Z.
Sathyanarayana, Sheela
Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort
title Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort
title_full Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort
title_fullStr Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort
title_full_unstemmed Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort
title_short Associations between Phthalate Exposure and Gestational Age at Delivery in a Diverse Pregnancy Cohort
title_sort associations between phthalate exposure and gestational age at delivery in a diverse pregnancy cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785862/
https://www.ncbi.nlm.nih.gov/pubmed/36548587
http://dx.doi.org/10.3390/toxics10120754
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