BRCA1/2 Reversion Mutations in Patients Treated with Poly ADP-Ribose Polymerase (PARP) Inhibitors or Platinum Agents

Background: Reversion mutations in BRCA1/2, resulting in restoration of the open reading frame, have been identified as a mechanism of resistance to platinum-based chemotherapy or PARP inhibition. We sought to explore the incidence of BRCA1/2 reversion mutations in different tumor types. Methods: We...

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Detalles Bibliográficos
Autores principales: Darabi, Sourat, Braxton, David R., Xiu, Joanne, Carneiro, Benedito A., Swensen, Jeff, Antonarakis, Emmanuel S., Liu, Stephen V., McKay, Rana R., Spetzler, David, El-Deiry, Wafik S., Demeure, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785940/
https://www.ncbi.nlm.nih.gov/pubmed/36557020
http://dx.doi.org/10.3390/medicina58121818

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