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Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects
Considering that it has been more than 24 months since SARS-CoV-2 emerged, it is crucial to identify measures that prevent and control pathogen transmission in workplace settings. Our aim was to report results of a hospital-based program that delivered hydroxychloroquine (HCQ) tablets as COVID-19 pr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786013/ https://www.ncbi.nlm.nih.gov/pubmed/36556412 http://dx.doi.org/10.3390/life12122047 |
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author | Shahrin, Lubaba Mahfuz, Mustafa Rahman, Md. Waliur Hossain, Md. Rezaul Khandaker, Afsana Mim Alam, Md. Ashraful Osmany, Din M. M. F. Islam, Md. Munirul Chisti, Mohammod Jobayer Ahmed, Chaudhury Meshkat Ahmed, Tahmeed |
author_facet | Shahrin, Lubaba Mahfuz, Mustafa Rahman, Md. Waliur Hossain, Md. Rezaul Khandaker, Afsana Mim Alam, Md. Ashraful Osmany, Din M. M. F. Islam, Md. Munirul Chisti, Mohammod Jobayer Ahmed, Chaudhury Meshkat Ahmed, Tahmeed |
author_sort | Shahrin, Lubaba |
collection | PubMed |
description | Considering that it has been more than 24 months since SARS-CoV-2 emerged, it is crucial to identify measures that prevent and control pathogen transmission in workplace settings. Our aim was to report results of a hospital-based program that delivered hydroxychloroquine (HCQ) tablets as COVID-19 prophylaxis to the frontline healthcare workers (HCW)s who cared for COVID-19 patients and to evaluate the efficacy of HCQ. Setting and participants: Quasi-experimental, controlled, single-center study. The included participants were doctors, nurses, health workers, cleaning staff, and non-healthcare supportive staff. The main outcome was contracting COVID-19 anytime during the period of taking the prophylaxis, confirmed by RT-PCR. A total of 336 participants, without any clinical evidence of COVID-19 and without any known contact with family members, were included in the trial; 230 were assigned to HCQ and 106 declined to take any drug. Results: Among the participants, 43 (18.7%) in the HCQ group and 11 (10.4%) participants in the control group developed COVID-19. For the evaluation of side effects, we evaluated 12-lead ECGs of both groups at the baseline and after 4 weeks to monitor QTc interval. A total of 91% (198 of 217) participants in the prophylaxis group and 92% (11 of 12) in the control group had a QTc < 45o msec, which is within normal limits. Conclusions: Although the number of symptomatic infections in health personnel was lower in the control group, the difference was not statistically significant. However, in the absence of any effective pre-exposure prophylaxis medicine for COVID-19, practicing proper infection prevention and control (IPC) and vaccination is the only way forward. |
format | Online Article Text |
id | pubmed-9786013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97860132022-12-24 Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects Shahrin, Lubaba Mahfuz, Mustafa Rahman, Md. Waliur Hossain, Md. Rezaul Khandaker, Afsana Mim Alam, Md. Ashraful Osmany, Din M. M. F. Islam, Md. Munirul Chisti, Mohammod Jobayer Ahmed, Chaudhury Meshkat Ahmed, Tahmeed Life (Basel) Article Considering that it has been more than 24 months since SARS-CoV-2 emerged, it is crucial to identify measures that prevent and control pathogen transmission in workplace settings. Our aim was to report results of a hospital-based program that delivered hydroxychloroquine (HCQ) tablets as COVID-19 prophylaxis to the frontline healthcare workers (HCW)s who cared for COVID-19 patients and to evaluate the efficacy of HCQ. Setting and participants: Quasi-experimental, controlled, single-center study. The included participants were doctors, nurses, health workers, cleaning staff, and non-healthcare supportive staff. The main outcome was contracting COVID-19 anytime during the period of taking the prophylaxis, confirmed by RT-PCR. A total of 336 participants, without any clinical evidence of COVID-19 and without any known contact with family members, were included in the trial; 230 were assigned to HCQ and 106 declined to take any drug. Results: Among the participants, 43 (18.7%) in the HCQ group and 11 (10.4%) participants in the control group developed COVID-19. For the evaluation of side effects, we evaluated 12-lead ECGs of both groups at the baseline and after 4 weeks to monitor QTc interval. A total of 91% (198 of 217) participants in the prophylaxis group and 92% (11 of 12) in the control group had a QTc < 45o msec, which is within normal limits. Conclusions: Although the number of symptomatic infections in health personnel was lower in the control group, the difference was not statistically significant. However, in the absence of any effective pre-exposure prophylaxis medicine for COVID-19, practicing proper infection prevention and control (IPC) and vaccination is the only way forward. MDPI 2022-12-07 /pmc/articles/PMC9786013/ /pubmed/36556412 http://dx.doi.org/10.3390/life12122047 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shahrin, Lubaba Mahfuz, Mustafa Rahman, Md. Waliur Hossain, Md. Rezaul Khandaker, Afsana Mim Alam, Md. Ashraful Osmany, Din M. M. F. Islam, Md. Munirul Chisti, Mohammod Jobayer Ahmed, Chaudhury Meshkat Ahmed, Tahmeed Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects |
title | Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects |
title_full | Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects |
title_fullStr | Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects |
title_full_unstemmed | Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects |
title_short | Hospital-Based Quasi-Experimental Study on Hydroxychloroquine Pre-Exposure Prophylaxis for COVID-19 in Healthcare Providers with Its Potential Side-Effects |
title_sort | hospital-based quasi-experimental study on hydroxychloroquine pre-exposure prophylaxis for covid-19 in healthcare providers with its potential side-effects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786013/ https://www.ncbi.nlm.nih.gov/pubmed/36556412 http://dx.doi.org/10.3390/life12122047 |
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