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Is the Stalk of the SARS-CoV-2 Spike Protein Druggable?

The spike protein is key to SARS-CoV-2 high infectivity because it facilitates the receptor binding domain (RBD) encounter with ACE2. As targeting subunit S1 has not yet delivered an ACE2-binding inhibitor, we have assessed the druggability of the conserved segment of the spike protein stalk within...

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Detalles Bibliográficos
Autores principales:	Pipitò, Ludovico, Reynolds, Christopher A., Deganutti, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786045/ https://www.ncbi.nlm.nih.gov/pubmed/36560795 http://dx.doi.org/10.3390/v14122789

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