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The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni
Campylobacter jejuni is a bacterial pathogen recognised as a major cause of foodborne illness worldwide. While Campylobacter jejuni generally does not grow outside its host, it can survive outside of the host long enough to pose a health concern. This review presents an up-to-date description and ev...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786101/ https://www.ncbi.nlm.nih.gov/pubmed/36557751 http://dx.doi.org/10.3390/microorganisms10122498 |
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author | Dzianach, Paulina A. Pérez-Reche, Francisco J. Strachan, Norval J. C. Forbes, Ken J. Dykes, Gary A. |
author_facet | Dzianach, Paulina A. Pérez-Reche, Francisco J. Strachan, Norval J. C. Forbes, Ken J. Dykes, Gary A. |
author_sort | Dzianach, Paulina A. |
collection | PubMed |
description | Campylobacter jejuni is a bacterial pathogen recognised as a major cause of foodborne illness worldwide. While Campylobacter jejuni generally does not grow outside its host, it can survive outside of the host long enough to pose a health concern. This review presents an up-to-date description and evaluation of biological, mathematical, and statistical approaches used to understand the behaviour of this foodborne pathogen and suggests future avenues which can be explored. Specifically, the incorporation of mathematical modelling may aid the understanding of C. jejuni biofilm formation both outside and inside the host. Predictive studies may be improved by the introduction of more standardised protocols for assessments of disinfection methods and by assessment of novel physical disinfection strategies as well as assessment of the efficiency of plant extracts on C. jejuni eradication. A full description of the metabolic pathways of C. jejuni, which is needed for the successful application of metabolic models, is yet to be achieved. Finally, a shift from animal models (except for those that are a source of human campylobacteriosis) to human-specific data may be made possible due to recent technological advancements, and this may lead to more accurate predictions of human infections. |
format | Online Article Text |
id | pubmed-9786101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97861012022-12-24 The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni Dzianach, Paulina A. Pérez-Reche, Francisco J. Strachan, Norval J. C. Forbes, Ken J. Dykes, Gary A. Microorganisms Review Campylobacter jejuni is a bacterial pathogen recognised as a major cause of foodborne illness worldwide. While Campylobacter jejuni generally does not grow outside its host, it can survive outside of the host long enough to pose a health concern. This review presents an up-to-date description and evaluation of biological, mathematical, and statistical approaches used to understand the behaviour of this foodborne pathogen and suggests future avenues which can be explored. Specifically, the incorporation of mathematical modelling may aid the understanding of C. jejuni biofilm formation both outside and inside the host. Predictive studies may be improved by the introduction of more standardised protocols for assessments of disinfection methods and by assessment of novel physical disinfection strategies as well as assessment of the efficiency of plant extracts on C. jejuni eradication. A full description of the metabolic pathways of C. jejuni, which is needed for the successful application of metabolic models, is yet to be achieved. Finally, a shift from animal models (except for those that are a source of human campylobacteriosis) to human-specific data may be made possible due to recent technological advancements, and this may lead to more accurate predictions of human infections. MDPI 2022-12-16 /pmc/articles/PMC9786101/ /pubmed/36557751 http://dx.doi.org/10.3390/microorganisms10122498 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dzianach, Paulina A. Pérez-Reche, Francisco J. Strachan, Norval J. C. Forbes, Ken J. Dykes, Gary A. The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni |
title | The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni |
title_full | The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni |
title_fullStr | The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni |
title_full_unstemmed | The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni |
title_short | The Use of Interdisciplinary Approaches to Understand the Biology of Campylobacter jejuni |
title_sort | use of interdisciplinary approaches to understand the biology of campylobacter jejuni |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786101/ https://www.ncbi.nlm.nih.gov/pubmed/36557751 http://dx.doi.org/10.3390/microorganisms10122498 |
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