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Determination of Leuprolide–Fatty Acid Conjugate in Rat Plasma Using LC-MS/MS and Its Pharmacokinetics after Subcutaneous Administration in Rats

Leuprolide is a synthetic nonapeptide drug (pyroGlu-His-Trp-Ser-Tyr-d-Leu-Leu-Arg-Pro-NHEt) that acts as a gonadotropin-releasing hormone agonist. The continuous administration of therapeutic doses of leuprolide inhibits gonadotropin secretion, which is used in androgen-deprivation therapy for the t...

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Detalles Bibliográficos
Autores principales:	Seong, Gi-Sang, Seo, Seong-Wook, Cho, Ji Young, Lee, Kye Wan, Lee, Beom-Jin, Yoon, In-Soo, Jin, Hyo-Eon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786172/ https://www.ncbi.nlm.nih.gov/pubmed/36557850 http://dx.doi.org/10.3390/molecules27248716

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