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Phytochemistry and Biological Activities of Guarea Genus (Meliaceae)
Guarea is one of the largest genera of the American Meliaceae family, consisting of over 69 species which are widely distributed in Mexico, Argentina, and Africa and are used in traditional medicine for several diseases. Previous studies reported that the Guarea species produce secondary metabolites...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786185/ https://www.ncbi.nlm.nih.gov/pubmed/36557891 http://dx.doi.org/10.3390/molecules27248758 |
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author | Safriansyah, Wahyu Sinaga, Siska Elisahbet Supratman, Unang Harneti, Desi |
author_facet | Safriansyah, Wahyu Sinaga, Siska Elisahbet Supratman, Unang Harneti, Desi |
author_sort | Safriansyah, Wahyu |
collection | PubMed |
description | Guarea is one of the largest genera of the American Meliaceae family, consisting of over 69 species which are widely distributed in Mexico, Argentina, and Africa and are used in traditional medicine for several diseases. Previous studies reported that the Guarea species produce secondary metabolites such as sesquiterpenoid, diterpenoid, triterpenoid, limonoid, steroid, and aromatic compounds. The preliminary chemical investigation commenced by isolating the limonoid compound, dihydrogedunin, in 1962; then, 240 compounds were obtained from the isolation and hydrodistillation process. Meanwhile, sesquiterpenoid is a significant compound with 52% of Guarea species. The extract and compounds were evaluated for their anti-inflammation, antimalarial, antiparasitic, antiprotozoal, antiviral, antimicrobial, insecticidal, antioxidant, phosphorylation inhibitor, and cytotoxic biological activities. The Guarea genus has also been reported as one of the sources of active compounds for medicinal chemistry. This review summarizes some descriptions regarding the types of Guarea species, especially ethnobotany and ethnopharmacology, such as the compounds isolated from the part of this genus, various isolation methods, and their bioactivities. The information can be used in further investigations to obtain more bioactive compounds and their reaction mechanisms. |
format | Online Article Text |
id | pubmed-9786185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97861852022-12-24 Phytochemistry and Biological Activities of Guarea Genus (Meliaceae) Safriansyah, Wahyu Sinaga, Siska Elisahbet Supratman, Unang Harneti, Desi Molecules Review Guarea is one of the largest genera of the American Meliaceae family, consisting of over 69 species which are widely distributed in Mexico, Argentina, and Africa and are used in traditional medicine for several diseases. Previous studies reported that the Guarea species produce secondary metabolites such as sesquiterpenoid, diterpenoid, triterpenoid, limonoid, steroid, and aromatic compounds. The preliminary chemical investigation commenced by isolating the limonoid compound, dihydrogedunin, in 1962; then, 240 compounds were obtained from the isolation and hydrodistillation process. Meanwhile, sesquiterpenoid is a significant compound with 52% of Guarea species. The extract and compounds were evaluated for their anti-inflammation, antimalarial, antiparasitic, antiprotozoal, antiviral, antimicrobial, insecticidal, antioxidant, phosphorylation inhibitor, and cytotoxic biological activities. The Guarea genus has also been reported as one of the sources of active compounds for medicinal chemistry. This review summarizes some descriptions regarding the types of Guarea species, especially ethnobotany and ethnopharmacology, such as the compounds isolated from the part of this genus, various isolation methods, and their bioactivities. The information can be used in further investigations to obtain more bioactive compounds and their reaction mechanisms. MDPI 2022-12-10 /pmc/articles/PMC9786185/ /pubmed/36557891 http://dx.doi.org/10.3390/molecules27248758 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Safriansyah, Wahyu Sinaga, Siska Elisahbet Supratman, Unang Harneti, Desi Phytochemistry and Biological Activities of Guarea Genus (Meliaceae) |
title | Phytochemistry and Biological Activities of Guarea Genus (Meliaceae) |
title_full | Phytochemistry and Biological Activities of Guarea Genus (Meliaceae) |
title_fullStr | Phytochemistry and Biological Activities of Guarea Genus (Meliaceae) |
title_full_unstemmed | Phytochemistry and Biological Activities of Guarea Genus (Meliaceae) |
title_short | Phytochemistry and Biological Activities of Guarea Genus (Meliaceae) |
title_sort | phytochemistry and biological activities of guarea genus (meliaceae) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786185/ https://www.ncbi.nlm.nih.gov/pubmed/36557891 http://dx.doi.org/10.3390/molecules27248758 |
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