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Molecular Modeling of Cardiac Sodium Channel with Mexiletine
A sodium channel blocker mexiletine (MEX) is used to treat chronic pain, myotonia and some arrhythmias. Mutations in the pore domain (PD) of voltage-gated sodium channels differently affect tonic block (TB) and use-dependent block (UDB) by MEX. Previous studies identified several MEX-sensing residue...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786191/ https://www.ncbi.nlm.nih.gov/pubmed/36557159 http://dx.doi.org/10.3390/membranes12121252 |