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Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury
Exposure to aristolochic acid (AA) is of increased concern due to carcinogenic and nephrotoxic effects, and incidence of aristolochic acid nephropathy (AAN) is increasing. This study characterizes renal alterations during the acute phase of AAN using parametric magnetic resonance imaging (MRI). An A...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786286/ https://www.ncbi.nlm.nih.gov/pubmed/36548535 http://dx.doi.org/10.3390/tomography8060243 |
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author | Mei, Yingjie Yang, Guixiang Guo, Yihao Zhao, Kaixuan Wu, Shuyu Xu, Zhongbiao Zhou, Shan Yan, Chenggong Seeliger, Erdmann Niendorf, Thoralf Xu, Yikai Feng, Yanqiu |
author_facet | Mei, Yingjie Yang, Guixiang Guo, Yihao Zhao, Kaixuan Wu, Shuyu Xu, Zhongbiao Zhou, Shan Yan, Chenggong Seeliger, Erdmann Niendorf, Thoralf Xu, Yikai Feng, Yanqiu |
author_sort | Mei, Yingjie |
collection | PubMed |
description | Exposure to aristolochic acid (AA) is of increased concern due to carcinogenic and nephrotoxic effects, and incidence of aristolochic acid nephropathy (AAN) is increasing. This study characterizes renal alterations during the acute phase of AAN using parametric magnetic resonance imaging (MRI). An AAN and a control group of male Wistar rats received administration of aristolochic acid I (AAI) and polyethylene glycol (PEG), respectively, for six days. Both groups underwent MRI before and 2, 4 and 6 days after AAI or PEG administration. T(2) relaxation times and apparent diffusion coefficients (ADCs) were determined for four renal layers. Serum creatinine levels (sCr) and blood urea nitrogen (BUN) were measured. Tubular injury scores (TIS) were evaluated based on histologic findings. Increased T(2) values were detected since day 2 in the AAN group, but decreased ADCs and increased sCr levels and BUN were not detected until day 4. Significant linear correlations were observed between T(2) of the cortex and the outer stripe of outer medulla and TIS. Our results demonstrate that parametric MRI facilitates early detection of renal injury induced by AAI in a rat model. T(2) mapping may be a valuable tool for assessing kidney injury during the acute phase of AAN. |
format | Online Article Text |
id | pubmed-9786286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97862862022-12-24 Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury Mei, Yingjie Yang, Guixiang Guo, Yihao Zhao, Kaixuan Wu, Shuyu Xu, Zhongbiao Zhou, Shan Yan, Chenggong Seeliger, Erdmann Niendorf, Thoralf Xu, Yikai Feng, Yanqiu Tomography Article Exposure to aristolochic acid (AA) is of increased concern due to carcinogenic and nephrotoxic effects, and incidence of aristolochic acid nephropathy (AAN) is increasing. This study characterizes renal alterations during the acute phase of AAN using parametric magnetic resonance imaging (MRI). An AAN and a control group of male Wistar rats received administration of aristolochic acid I (AAI) and polyethylene glycol (PEG), respectively, for six days. Both groups underwent MRI before and 2, 4 and 6 days after AAI or PEG administration. T(2) relaxation times and apparent diffusion coefficients (ADCs) were determined for four renal layers. Serum creatinine levels (sCr) and blood urea nitrogen (BUN) were measured. Tubular injury scores (TIS) were evaluated based on histologic findings. Increased T(2) values were detected since day 2 in the AAN group, but decreased ADCs and increased sCr levels and BUN were not detected until day 4. Significant linear correlations were observed between T(2) of the cortex and the outer stripe of outer medulla and TIS. Our results demonstrate that parametric MRI facilitates early detection of renal injury induced by AAI in a rat model. T(2) mapping may be a valuable tool for assessing kidney injury during the acute phase of AAN. MDPI 2022-12-10 /pmc/articles/PMC9786286/ /pubmed/36548535 http://dx.doi.org/10.3390/tomography8060243 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mei, Yingjie Yang, Guixiang Guo, Yihao Zhao, Kaixuan Wu, Shuyu Xu, Zhongbiao Zhou, Shan Yan, Chenggong Seeliger, Erdmann Niendorf, Thoralf Xu, Yikai Feng, Yanqiu Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury |
title | Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury |
title_full | Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury |
title_fullStr | Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury |
title_full_unstemmed | Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury |
title_short | Parametric MRI Detects Aristolochic Acid Induced Acute Kidney Injury |
title_sort | parametric mri detects aristolochic acid induced acute kidney injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786286/ https://www.ncbi.nlm.nih.gov/pubmed/36548535 http://dx.doi.org/10.3390/tomography8060243 |
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