A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination

We report a case of vasospastic angina (VSA) following COVID-19 mRNA vaccination. Despite the widespread occurrence of myocarditis, there have been few reports of post-vaccinal VSA. A 41-year-old male patient was referred for chest pain at rest following mRNA vaccination; he had never experienced ch...

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Autores principales: Awaya, Toru, Moroi, Masao, Nakamura, Fuminori, Toi, Satoru, Wakiya, Momoko, Enomoto, Yoshinari, Kunimasa, Taeko, Nakamura, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786293/
https://www.ncbi.nlm.nih.gov/pubmed/36560408
http://dx.doi.org/10.3390/vaccines10121998
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author Awaya, Toru
Moroi, Masao
Nakamura, Fuminori
Toi, Satoru
Wakiya, Momoko
Enomoto, Yoshinari
Kunimasa, Taeko
Nakamura, Masato
author_facet Awaya, Toru
Moroi, Masao
Nakamura, Fuminori
Toi, Satoru
Wakiya, Momoko
Enomoto, Yoshinari
Kunimasa, Taeko
Nakamura, Masato
author_sort Awaya, Toru
collection PubMed
description We report a case of vasospastic angina (VSA) following COVID-19 mRNA vaccination. Despite the widespread occurrence of myocarditis, there have been few reports of post-vaccinal VSA. A 41-year-old male patient was referred for chest pain at rest following mRNA vaccination; he had never experienced chest pain prior to vaccination. He was diagnosed by an acetylcholine (Ach) provocation test that showed multivessel vasospasm. After the initiation of treatment with a calcium channel blocker and nitrate, no further exacerbation of chest pain was observed. To our knowledge, this constitutes the first reported case of VSA proven by Ach provocation test after COVID-19 vaccination. The vaccination may increase coronary artery spasticity. VSA should be ruled out in post-vaccine new onset resting chest pain.
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spelling pubmed-97862932022-12-24 A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination Awaya, Toru Moroi, Masao Nakamura, Fuminori Toi, Satoru Wakiya, Momoko Enomoto, Yoshinari Kunimasa, Taeko Nakamura, Masato Vaccines (Basel) Case Report We report a case of vasospastic angina (VSA) following COVID-19 mRNA vaccination. Despite the widespread occurrence of myocarditis, there have been few reports of post-vaccinal VSA. A 41-year-old male patient was referred for chest pain at rest following mRNA vaccination; he had never experienced chest pain prior to vaccination. He was diagnosed by an acetylcholine (Ach) provocation test that showed multivessel vasospasm. After the initiation of treatment with a calcium channel blocker and nitrate, no further exacerbation of chest pain was observed. To our knowledge, this constitutes the first reported case of VSA proven by Ach provocation test after COVID-19 vaccination. The vaccination may increase coronary artery spasticity. VSA should be ruled out in post-vaccine new onset resting chest pain. MDPI 2022-11-24 /pmc/articles/PMC9786293/ /pubmed/36560408 http://dx.doi.org/10.3390/vaccines10121998 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Awaya, Toru
Moroi, Masao
Nakamura, Fuminori
Toi, Satoru
Wakiya, Momoko
Enomoto, Yoshinari
Kunimasa, Taeko
Nakamura, Masato
A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination
title A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination
title_full A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination
title_fullStr A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination
title_full_unstemmed A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination
title_short A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination
title_sort possibility of vasospastic angina after mrna covid-19 vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786293/
https://www.ncbi.nlm.nih.gov/pubmed/36560408
http://dx.doi.org/10.3390/vaccines10121998
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