Cargando…

Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia

BACKGROUND: Little is known regarding the dose‐response function in multidomain interventions for dementia prevention. METHOD: The Multidomain Alzheimer Preventive Trial is a 3‐year randomized controlled trial comprising cognitive training, physical activity, nutrition, and omega‐3 polyunsaturated f...

Descripción completa

Detalles Bibliográficos
Autores principales: Belleville, Sylvie, Cloutier, Simon, Mellah, Samira, Willis, Sherry, Vellas, Bruno, Andrieu, Sandrine, Coley, Nicola, Ngandu, Tiia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786573/
https://www.ncbi.nlm.nih.gov/pubmed/35049127
http://dx.doi.org/10.1002/alz.12544
_version_ 1784858318146109440
author Belleville, Sylvie
Cloutier, Simon
Mellah, Samira
Willis, Sherry
Vellas, Bruno
Andrieu, Sandrine
Coley, Nicola
Ngandu, Tiia
author_facet Belleville, Sylvie
Cloutier, Simon
Mellah, Samira
Willis, Sherry
Vellas, Bruno
Andrieu, Sandrine
Coley, Nicola
Ngandu, Tiia
author_sort Belleville, Sylvie
collection PubMed
description BACKGROUND: Little is known regarding the dose‐response function in multidomain interventions for dementia prevention. METHOD: The Multidomain Alzheimer Preventive Trial is a 3‐year randomized controlled trial comprising cognitive training, physical activity, nutrition, and omega‐3 polyunsaturated fatty acids for at‐risk older adults. The dose delivered (number of sessions attended) was modeled against global cognition, memory, and fluency in 749 participants. Interaction effects were assessed for age, sex, education, dementia score (CAIDE), frailty score, and apolipoprotein E (APOE) ε4 status. RESULTS: The dose‐response models were non‐linear functions indicating benefits up to about 12 to 14 training hours or 15 to 20 multidomain sessions followed by a plateau. Participants who benefited from a higher dose included women, younger participants, frail individuals, and those with lower education or lower risk of dementia. DISCUSSION: The non‐linear function indicates that a higher dose is not necessarily better in multidomain interventions. The optimal dose was about half of the potentially available sessions.
format Online
Article
Text
id pubmed-9786573
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-97865732022-12-27 Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia Belleville, Sylvie Cloutier, Simon Mellah, Samira Willis, Sherry Vellas, Bruno Andrieu, Sandrine Coley, Nicola Ngandu, Tiia Alzheimers Dement Featured Articles BACKGROUND: Little is known regarding the dose‐response function in multidomain interventions for dementia prevention. METHOD: The Multidomain Alzheimer Preventive Trial is a 3‐year randomized controlled trial comprising cognitive training, physical activity, nutrition, and omega‐3 polyunsaturated fatty acids for at‐risk older adults. The dose delivered (number of sessions attended) was modeled against global cognition, memory, and fluency in 749 participants. Interaction effects were assessed for age, sex, education, dementia score (CAIDE), frailty score, and apolipoprotein E (APOE) ε4 status. RESULTS: The dose‐response models were non‐linear functions indicating benefits up to about 12 to 14 training hours or 15 to 20 multidomain sessions followed by a plateau. Participants who benefited from a higher dose included women, younger participants, frail individuals, and those with lower education or lower risk of dementia. DISCUSSION: The non‐linear function indicates that a higher dose is not necessarily better in multidomain interventions. The optimal dose was about half of the potentially available sessions. John Wiley and Sons Inc. 2022-01-20 2022-11 /pmc/articles/PMC9786573/ /pubmed/35049127 http://dx.doi.org/10.1002/alz.12544 Text en © 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Featured Articles
Belleville, Sylvie
Cloutier, Simon
Mellah, Samira
Willis, Sherry
Vellas, Bruno
Andrieu, Sandrine
Coley, Nicola
Ngandu, Tiia
Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia
title Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia
title_full Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia
title_fullStr Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia
title_full_unstemmed Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia
title_short Is more always better? Dose effect in a multidomain intervention in older adults at risk of dementia
title_sort is more always better? dose effect in a multidomain intervention in older adults at risk of dementia
topic Featured Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786573/
https://www.ncbi.nlm.nih.gov/pubmed/35049127
http://dx.doi.org/10.1002/alz.12544
work_keys_str_mv AT bellevillesylvie ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT cloutiersimon ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT mellahsamira ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT willissherry ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT vellasbruno ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT andrieusandrine ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT coleynicola ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT ngandutiia ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia
AT ismorealwaysbetterdoseeffectinamultidomaininterventioninolderadultsatriskofdementia