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Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes
Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786739/ https://www.ncbi.nlm.nih.gov/pubmed/36558133 http://dx.doi.org/10.3390/molecules27249000 |
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author | Di Pietro, Maria Letizia Stagno, Claudio Efferth, Thomas Omer, Ejlal A. D’Angelo, Valeria Germanò, Maria Paola Cacciola, Anna De Gaetano, Federica Iraci, Nunzio Micale, Nicola |
author_facet | Di Pietro, Maria Letizia Stagno, Claudio Efferth, Thomas Omer, Ejlal A. D’Angelo, Valeria Germanò, Maria Paola Cacciola, Anna De Gaetano, Federica Iraci, Nunzio Micale, Nicola |
author_sort | Di Pietro, Maria Letizia |
collection | PubMed |
description | Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study, we report a significant biological investigation into and computation analyses of four Pt(II)-complexes, namely, LDP-1–4, synthesized and characterized according to previously reported procedures. Molecular-modelling studies highlighted that the top two LDP compounds (i.e., LDP-1 and LDP-4) might bind to both matched and mismatched base pair sites of the oligonucleotide 5′-(dCGGAAATTACCG)(2)-3′, supporting their anticancer potential. These two complexes displayed noteworthy cytotoxicity in vitro (sub-micromolar–micromolar range) against two leukaemia cell lines, i.e., CCRF-CEM and its multi-drug-resistant counterpart CEM/ADR5000, and remarkable anti-angiogenic properties (in the sub-micromolar range) evaluated in an in vivo model, i.e., a chick embryo chorioallantoic membrane (CAM) assay. |
format | Online Article Text |
id | pubmed-9786739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97867392022-12-24 Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes Di Pietro, Maria Letizia Stagno, Claudio Efferth, Thomas Omer, Ejlal A. D’Angelo, Valeria Germanò, Maria Paola Cacciola, Anna De Gaetano, Federica Iraci, Nunzio Micale, Nicola Molecules Article Transition metal complexes have continued to constitute an appealing class of medicinal compounds since the exceptional discovery of cisplatin in the late 1960s. Pt(II)-based complexes are endowed with a broad range of biological properties, which are mainly exerted by targeting DNA. In this study, we report a significant biological investigation into and computation analyses of four Pt(II)-complexes, namely, LDP-1–4, synthesized and characterized according to previously reported procedures. Molecular-modelling studies highlighted that the top two LDP compounds (i.e., LDP-1 and LDP-4) might bind to both matched and mismatched base pair sites of the oligonucleotide 5′-(dCGGAAATTACCG)(2)-3′, supporting their anticancer potential. These two complexes displayed noteworthy cytotoxicity in vitro (sub-micromolar–micromolar range) against two leukaemia cell lines, i.e., CCRF-CEM and its multi-drug-resistant counterpart CEM/ADR5000, and remarkable anti-angiogenic properties (in the sub-micromolar range) evaluated in an in vivo model, i.e., a chick embryo chorioallantoic membrane (CAM) assay. MDPI 2022-12-17 /pmc/articles/PMC9786739/ /pubmed/36558133 http://dx.doi.org/10.3390/molecules27249000 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Di Pietro, Maria Letizia Stagno, Claudio Efferth, Thomas Omer, Ejlal A. D’Angelo, Valeria Germanò, Maria Paola Cacciola, Anna De Gaetano, Federica Iraci, Nunzio Micale, Nicola Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes |
title | Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes |
title_full | Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes |
title_fullStr | Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes |
title_full_unstemmed | Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes |
title_short | Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes |
title_sort | antileukemia activity and mechanism of platinum(ii)-based metal complexes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786739/ https://www.ncbi.nlm.nih.gov/pubmed/36558133 http://dx.doi.org/10.3390/molecules27249000 |
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