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Spanlastics as a Potential Platform for Enhancing the Brain Delivery of Flibanserin: In Vitro Response-Surface Optimization and In Vivo Pharmacokinetics Assessment

Flibanserin was licensed by the United States Food and Drug Administration (FDA) as an oral non-hormonal therapy for pre-menopausal women with inhibited sexual desire disorder. However, it suffers from susceptibility to first-pass metabolism in the liver, low aqueous solubility, and degradation in t...

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Detalles Bibliográficos
Autores principales:	Alharbi, Waleed S., Hareeri, Rawan H., Bazuhair, Mohammed, Alfaleh, Mohamed A., Alhakamy, Nabil A., Fahmy, Usama A., Alamoudi, Abdullah A., Badr-Eldin, Shaimaa M., Ahmed, Osama A., AlGhamdi, Shareefa A., Naguib, Marianne J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786754/ https://www.ncbi.nlm.nih.gov/pubmed/36559120 http://dx.doi.org/10.3390/pharmaceutics14122627

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