Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

The mutations G170R and I244T are the most common disease cause in primary hyperoxaluria type I (PH1). These mutations cause the misfolding of the AGT protein in the minor allele AGT-LM that contains the P11L polymorphism, which may affect the folding of the N-terminal segment (NTT-AGT). The NTT-AGT...

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Detalles Bibliográficos
Autores principales: Neira, Jose L., Naganathan, Athi N., Mesa-Torres, Noel, Salido, Eduardo, Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786777/
https://www.ncbi.nlm.nih.gov/pubmed/36557898
http://dx.doi.org/10.3390/molecules27248762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786777/
https://www.ncbi.nlm.nih.gov/pubmed/36557898
http://dx.doi.org/10.3390/molecules27248762

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