Parenteral Exposure of Mice to Ricin Toxin Induces Fatal Hypoglycemia by Cytokine-Mediated Suppression of Hepatic Glucose-6-Phosphatase Expression

Ricin toxin is an agent of biodefense concern and we have been developing countermeasures for ricin threats. In doing so, we sought biomarkers of ricin toxicosis and found that in mice parenteral injection of ricin toxin causes profound hypoglycemia, in the absence of other clinical laboratory abnor...

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Detalles Bibliográficos
Autores principales: Pincus, Seth H., Kyro, Alexi, Maresh, Grace A., Peters, Tami, Kempa, Jacob, Marcotte, Tamera K., Gao, Zhanguo, Ye, Jianping, Copié, Valérie, Song, Kejing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786807/
https://www.ncbi.nlm.nih.gov/pubmed/36548717
http://dx.doi.org/10.3390/toxins14120820

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