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Versatile Fluorine-Containing Building Blocks: β-CF(3)-1,3-enynes
The development of diversity-oriented synthesis based on fluorine-containing building blocks has been one of the hot research fields in fluorine chemistry. β-CF(3)-1,3-enynes, as one type of fluorine-containing building blocks, have attracted more attention in the last few years due to their distinc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786819/ https://www.ncbi.nlm.nih.gov/pubmed/36558151 http://dx.doi.org/10.3390/molecules27249020 |
Sumario: | The development of diversity-oriented synthesis based on fluorine-containing building blocks has been one of the hot research fields in fluorine chemistry. β-CF(3)-1,3-enynes, as one type of fluorine-containing building blocks, have attracted more attention in the last few years due to their distinct reactivity. Numerous value-added trifluoromethylated or non-fluorinated compounds which have biologically relevant structural motifs, such as O-, N-, and S-heterocycles, carboncycles, fused polycycles, and multifunctionalized allenes were synthesized from these fluorine-containing building blocks. This review summarizes the most significant developments in the area of synthesis of organofluorine compounds based on β-CF(3)-1,3-enynes, providing a detailed overview of the current state of the art. |
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