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Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application

Background: Laguna ONhE provides a globin distribution function (GDF), in which a glaucoma discriminator based on deep learning plays an important role, and there is also an optimized globin individual pointer (GIP) for progression analysis. Methods: Signs of optic nerve glaucoma were identified in...

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Autores principales: Gonzalez-Hernandez, Marta, Gonzalez-Hernandez, Daniel, Betancor-Caro, Nisamar, Guedes-Guedes, Isabel, Guldager, Morten Kirk, Gonzalez de la Rosa, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786827/
https://www.ncbi.nlm.nih.gov/pubmed/36555912
http://dx.doi.org/10.3390/jcm11247294
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author Gonzalez-Hernandez, Marta
Gonzalez-Hernandez, Daniel
Betancor-Caro, Nisamar
Guedes-Guedes, Isabel
Guldager, Morten Kirk
Gonzalez de la Rosa, Manuel
author_facet Gonzalez-Hernandez, Marta
Gonzalez-Hernandez, Daniel
Betancor-Caro, Nisamar
Guedes-Guedes, Isabel
Guldager, Morten Kirk
Gonzalez de la Rosa, Manuel
author_sort Gonzalez-Hernandez, Marta
collection PubMed
description Background: Laguna ONhE provides a globin distribution function (GDF), in which a glaucoma discriminator based on deep learning plays an important role, and there is also an optimized globin individual pointer (GIP) for progression analysis. Methods: Signs of optic nerve glaucoma were identified in 1,124,885 fundus images from 203,115 diabetics obtained over 15 years and 117,813 control images. Results: A total of 743,696 images from 313,040 eyes of 173,661 diabetics were analysed. Some exclusions occurred due to excessive illumination, poor quality, or the absence of optic discs. Suspicion of glaucoma was reported in 6.70%, for an intended specificity of 99% (GDF < −15). More signs of glaucoma occur in diabetics as their years of disease increase, and after age 60, compared to controls. The GIP detected progression (p < 0.01) in 2.59% of cases with 4 controls and in 42.6% with 14 controls was higher in cases with lower GDF values. The GDF was corrected for the disc area and proved to be independent of it (r = 0.001925; p = 0.2814). Conclusions: The GDF index suggests a higher and increasing glaucoma probability in diabetics over time. Doubling the number of check-ups from four to eight increases the ability to detect GIP index progression by a factor of 5.
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spelling pubmed-97868272022-12-24 Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application Gonzalez-Hernandez, Marta Gonzalez-Hernandez, Daniel Betancor-Caro, Nisamar Guedes-Guedes, Isabel Guldager, Morten Kirk Gonzalez de la Rosa, Manuel J Clin Med Article Background: Laguna ONhE provides a globin distribution function (GDF), in which a glaucoma discriminator based on deep learning plays an important role, and there is also an optimized globin individual pointer (GIP) for progression analysis. Methods: Signs of optic nerve glaucoma were identified in 1,124,885 fundus images from 203,115 diabetics obtained over 15 years and 117,813 control images. Results: A total of 743,696 images from 313,040 eyes of 173,661 diabetics were analysed. Some exclusions occurred due to excessive illumination, poor quality, or the absence of optic discs. Suspicion of glaucoma was reported in 6.70%, for an intended specificity of 99% (GDF < −15). More signs of glaucoma occur in diabetics as their years of disease increase, and after age 60, compared to controls. The GIP detected progression (p < 0.01) in 2.59% of cases with 4 controls and in 42.6% with 14 controls was higher in cases with lower GDF values. The GDF was corrected for the disc area and proved to be independent of it (r = 0.001925; p = 0.2814). Conclusions: The GDF index suggests a higher and increasing glaucoma probability in diabetics over time. Doubling the number of check-ups from four to eight increases the ability to detect GIP index progression by a factor of 5. MDPI 2022-12-08 /pmc/articles/PMC9786827/ /pubmed/36555912 http://dx.doi.org/10.3390/jcm11247294 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gonzalez-Hernandez, Marta
Gonzalez-Hernandez, Daniel
Betancor-Caro, Nisamar
Guedes-Guedes, Isabel
Guldager, Morten Kirk
Gonzalez de la Rosa, Manuel
Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application
title Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application
title_full Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application
title_fullStr Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application
title_full_unstemmed Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application
title_short Glaucoma Incidence and Progression in Diabetics: The Canary Islands Study Using the Laguna ONhE Application
title_sort glaucoma incidence and progression in diabetics: the canary islands study using the laguna onhe application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786827/
https://www.ncbi.nlm.nih.gov/pubmed/36555912
http://dx.doi.org/10.3390/jcm11247294
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