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Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery

In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities. Among the various active targeting moieties, chlorotoxin, a pepti...

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Autores principales: Shrestha, Archana, Lahooti, Behnaz, Mikelis, Constantinos M., Mattheolabakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786857/
https://www.ncbi.nlm.nih.gov/pubmed/36559106
http://dx.doi.org/10.3390/pharmaceutics14122613
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author Shrestha, Archana
Lahooti, Behnaz
Mikelis, Constantinos M.
Mattheolabakis, George
author_facet Shrestha, Archana
Lahooti, Behnaz
Mikelis, Constantinos M.
Mattheolabakis, George
author_sort Shrestha, Archana
collection PubMed
description In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities. Among the various active targeting moieties, chlorotoxin, a peptide extracted from scorpions, demonstrated promising tumor cell accumulation and selection. With lung cancer being among the leading diagnoses of cancer-related deaths in both men and women, novel therapeutic methodologies utilizing nanotechnology for drug delivery emerged. Given chlorotoxin’s promising biological activity, we explore its potential against lung cancer and its utilization for active targeting against this cancer’s tumor cells. Our analysis indicates that despite the extensive chlorotoxin’s research against glioblastoma, lung cancer research with the molecule has been limited, despite some promising early results.
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spelling pubmed-97868572022-12-24 Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery Shrestha, Archana Lahooti, Behnaz Mikelis, Constantinos M. Mattheolabakis, George Pharmaceutics Brief Report In the generational evolution of nano-based drug delivery carriers, active targeting has been a major milestone for improved and selective drug accumulation in tissues and cell types beyond the existing passive targeting capabilities. Among the various active targeting moieties, chlorotoxin, a peptide extracted from scorpions, demonstrated promising tumor cell accumulation and selection. With lung cancer being among the leading diagnoses of cancer-related deaths in both men and women, novel therapeutic methodologies utilizing nanotechnology for drug delivery emerged. Given chlorotoxin’s promising biological activity, we explore its potential against lung cancer and its utilization for active targeting against this cancer’s tumor cells. Our analysis indicates that despite the extensive chlorotoxin’s research against glioblastoma, lung cancer research with the molecule has been limited, despite some promising early results. MDPI 2022-11-26 /pmc/articles/PMC9786857/ /pubmed/36559106 http://dx.doi.org/10.3390/pharmaceutics14122613 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Shrestha, Archana
Lahooti, Behnaz
Mikelis, Constantinos M.
Mattheolabakis, George
Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
title Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
title_full Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
title_fullStr Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
title_full_unstemmed Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
title_short Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery
title_sort chlorotoxin and lung cancer: a targeting perspective for drug delivery
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786857/
https://www.ncbi.nlm.nih.gov/pubmed/36559106
http://dx.doi.org/10.3390/pharmaceutics14122613
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