Identification and characterization of murine glycoprotein 2‐expressing intestinal dendritic cells

The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non‐redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI‐anchored protein and receptor for bacterial type‐I fimbriae, is selectively expressed...

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Detalles Bibliográficos
Autores principales: Luda, Katarzyna M., Da Silva, Clement, Ahmadi, Fatemeh, Mowat, Allan Mcl., Ohno, Hiroshi, Kotarsky, Knut, Agace, William W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786990/
https://www.ncbi.nlm.nih.gov/pubmed/37807915
http://dx.doi.org/10.1111/sji.13219
Descripción
Sumario:The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non‐redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI‐anchored protein and receptor for bacterial type‐I fimbriae, is selectively expressed by CD103(+)CD11b(+) cDC in the murine small intestine (SI). GP2 expression was induced on CD103(+)CD11b(+) cDC within the SI‐LP and was regulated by IRF4, TGFβR1‐ and retinoic acid signalling. Mice selectively lacking Gp2 on CD103(+)CD11b(+) cDC (huLang‐Cre.gp2 ( fl/fl ) mice) had normal numbers and proportions of innate and adaptive immune cells in the SI‐LP suggesting that GP2 expression by CD103(+)CD11b(+) cDC is not required for intestinal immune homoeostasis.

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