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Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum

During the last few decades, efforts to increase the safety of blood and blood products have mainly focused on preventing the viral infections HCV, HIV, HBV and Treponema pallidum. The evolution of these approaches and the achieved increase in safety is shown for the last 25 years in Switzerland. In...

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Autores principales: Niederhauser, Christoph, Tinguely, Caroline, Stolz, Martin, Vock, Michael, El Dusouqui, Soraya Amar, Gowland, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787333/
https://www.ncbi.nlm.nih.gov/pubmed/36560615
http://dx.doi.org/10.3390/v14122611
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author Niederhauser, Christoph
Tinguely, Caroline
Stolz, Martin
Vock, Michael
El Dusouqui, Soraya Amar
Gowland, Peter
author_facet Niederhauser, Christoph
Tinguely, Caroline
Stolz, Martin
Vock, Michael
El Dusouqui, Soraya Amar
Gowland, Peter
author_sort Niederhauser, Christoph
collection PubMed
description During the last few decades, efforts to increase the safety of blood and blood products have mainly focused on preventing the viral infections HCV, HIV, HBV and Treponema pallidum. The evolution of these approaches and the achieved increase in safety is shown for the last 25 years in Switzerland. In detail, the prevalences and incidences of the infection disease and the theoretical estimated residual risks (RR) of these blood-borne infections are presented. Prevalences, incidences and, in particular, the RR have decreased considerably over the last 25 years. This was achieved primarily by the adoption of strict criteria for the selection of blood donors, refined questionnaires, the introduction of increasingly sensitive serological screening tests and the implementation of nucleic acid testing (NAT) for these blood-borne pathogens. These NAT assays have significantly shortened the window period between infection and the first detection of the infectious agent in the blood of an infected individual. A form of “real life” comparison or confirmation is provided by the reported lookback procedures (LBP) and the haemovigilance data of the Swiss competent authority, Swissmedic. These data are in agreement, and thus support the very low prevalences, incidences and RR.
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spelling pubmed-97873332022-12-24 Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum Niederhauser, Christoph Tinguely, Caroline Stolz, Martin Vock, Michael El Dusouqui, Soraya Amar Gowland, Peter Viruses Article During the last few decades, efforts to increase the safety of blood and blood products have mainly focused on preventing the viral infections HCV, HIV, HBV and Treponema pallidum. The evolution of these approaches and the achieved increase in safety is shown for the last 25 years in Switzerland. In detail, the prevalences and incidences of the infection disease and the theoretical estimated residual risks (RR) of these blood-borne infections are presented. Prevalences, incidences and, in particular, the RR have decreased considerably over the last 25 years. This was achieved primarily by the adoption of strict criteria for the selection of blood donors, refined questionnaires, the introduction of increasingly sensitive serological screening tests and the implementation of nucleic acid testing (NAT) for these blood-borne pathogens. These NAT assays have significantly shortened the window period between infection and the first detection of the infectious agent in the blood of an infected individual. A form of “real life” comparison or confirmation is provided by the reported lookback procedures (LBP) and the haemovigilance data of the Swiss competent authority, Swissmedic. These data are in agreement, and thus support the very low prevalences, incidences and RR. MDPI 2022-11-23 /pmc/articles/PMC9787333/ /pubmed/36560615 http://dx.doi.org/10.3390/v14122611 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Niederhauser, Christoph
Tinguely, Caroline
Stolz, Martin
Vock, Michael
El Dusouqui, Soraya Amar
Gowland, Peter
Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum
title Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum
title_full Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum
title_fullStr Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum
title_full_unstemmed Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum
title_short Evolution of Blood Safety in Switzerland over the Last 25 Years for HIV, HCV, HBV and Treponema pallidum
title_sort evolution of blood safety in switzerland over the last 25 years for hiv, hcv, hbv and treponema pallidum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787333/
https://www.ncbi.nlm.nih.gov/pubmed/36560615
http://dx.doi.org/10.3390/v14122611
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