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Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+

INTRODUCTION: We hypothesized that lower untreated systolic blood pressure (SBP) would be associated with a lower risk of dementia and death up to age 95. METHODS: SBP measured between 2000 and 2006 was evaluated in relationship to dementia risk and brain biomarkers from 2009‐2020 (n = 177) in the G...

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Autores principales: Kuller, Lewis H., Snitz, Beth E., Hughes, Timothy M., Chang, Yuefang, Cohen, Ann D., Mathis, Chester A., Aizenstein, Howard J., Lopez, Oscar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787390/
https://www.ncbi.nlm.nih.gov/pubmed/35089640
http://dx.doi.org/10.1002/alz.12493
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author Kuller, Lewis H.
Snitz, Beth E.
Hughes, Timothy M.
Chang, Yuefang
Cohen, Ann D.
Mathis, Chester A.
Aizenstein, Howard J.
Lopez, Oscar L.
author_facet Kuller, Lewis H.
Snitz, Beth E.
Hughes, Timothy M.
Chang, Yuefang
Cohen, Ann D.
Mathis, Chester A.
Aizenstein, Howard J.
Lopez, Oscar L.
author_sort Kuller, Lewis H.
collection PubMed
description INTRODUCTION: We hypothesized that lower untreated systolic blood pressure (SBP) would be associated with a lower risk of dementia and death up to age 95. METHODS: SBP measured between 2000 and 2006 was evaluated in relationship to dementia risk and brain biomarkers from 2009‐2020 (n = 177) in the Gingko Evaluation of Memory Study (GEMS), mean age 95 in 2020. Participants had measurements of brain amyloid beta (Aβ) and repeat clinical‐cognitive evaluations every 6 months. RESULTS: By 2020, only 9 of 177 patients (5%) were alive and cognitively unimpaired (CU). Mean SBP from 2000 to 2006 was 120 mm Hg for nine alive/CU, 125 mm Hg for alive/mild cognitive impairment (MCI), and 130 mm Hg for alive/dementia (P = .03). The amount of Aβ was directly related to SBP levels. In multivariate analysis, Aβ+ in 2009 and thinner cortex were significant predictors of dementia. Excluding Aβ, SBP became a significant predictor of dementia. DISCUSSION: Low SBP untreated by antihypertensive medications was associated with significant decreased risk of dementia and less Aβ.
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spelling pubmed-97873902022-12-27 Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+ Kuller, Lewis H. Snitz, Beth E. Hughes, Timothy M. Chang, Yuefang Cohen, Ann D. Mathis, Chester A. Aizenstein, Howard J. Lopez, Oscar L. Alzheimers Dement Featured Articles INTRODUCTION: We hypothesized that lower untreated systolic blood pressure (SBP) would be associated with a lower risk of dementia and death up to age 95. METHODS: SBP measured between 2000 and 2006 was evaluated in relationship to dementia risk and brain biomarkers from 2009‐2020 (n = 177) in the Gingko Evaluation of Memory Study (GEMS), mean age 95 in 2020. Participants had measurements of brain amyloid beta (Aβ) and repeat clinical‐cognitive evaluations every 6 months. RESULTS: By 2020, only 9 of 177 patients (5%) were alive and cognitively unimpaired (CU). Mean SBP from 2000 to 2006 was 120 mm Hg for nine alive/CU, 125 mm Hg for alive/mild cognitive impairment (MCI), and 130 mm Hg for alive/dementia (P = .03). The amount of Aβ was directly related to SBP levels. In multivariate analysis, Aβ+ in 2009 and thinner cortex were significant predictors of dementia. Excluding Aβ, SBP became a significant predictor of dementia. DISCUSSION: Low SBP untreated by antihypertensive medications was associated with significant decreased risk of dementia and less Aβ. John Wiley and Sons Inc. 2022-01-28 2022-11 /pmc/articles/PMC9787390/ /pubmed/35089640 http://dx.doi.org/10.1002/alz.12493 Text en © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Featured Articles
Kuller, Lewis H.
Snitz, Beth E.
Hughes, Timothy M.
Chang, Yuefang
Cohen, Ann D.
Mathis, Chester A.
Aizenstein, Howard J.
Lopez, Oscar L.
Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+
title Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+
title_full Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+
title_fullStr Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+
title_full_unstemmed Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+
title_short Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+
title_sort low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+
topic Featured Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787390/
https://www.ncbi.nlm.nih.gov/pubmed/35089640
http://dx.doi.org/10.1002/alz.12493
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