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The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter?

Background: Takotsubo syndrome (TTS) is a unique type of reversible cardiomyopathy that predominantly affects elderly women. The role of physical and emotional stress in the pathophysiology of TTS is well established. However, the association between preceding emotional triggers and clinical outcome...

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Autores principales: Moady, Gassan, Ali, Otman, Sweid, Rania, Atar, Shaul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787463/
https://www.ncbi.nlm.nih.gov/pubmed/36555921
http://dx.doi.org/10.3390/jcm11247304
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author Moady, Gassan
Ali, Otman
Sweid, Rania
Atar, Shaul
author_facet Moady, Gassan
Ali, Otman
Sweid, Rania
Atar, Shaul
author_sort Moady, Gassan
collection PubMed
description Background: Takotsubo syndrome (TTS) is a unique type of reversible cardiomyopathy that predominantly affects elderly women. The role of physical and emotional stress in the pathophysiology of TTS is well established. However, the association between preceding emotional triggers and clinical outcomes in stable patients has not yet been fully investigated. We aimed to investigate the association between emotional triggers before symptom onset and clinical outcomes in stable patients with TTS. Methods: This is a retrospective cohort study based on the data of patients with ICD-9 discharge diagnosis of TTS between 2017 and 2022. Patients were divided into two groups: with and without obvious emotional trigger before symptom onset. Demographic, laboratory, echocardiographic, and clinical outcomes were obtained and compared between the two groups. Results: We included 86 patients (93% were women, mean age 68.8 ± 12.3 years). Of them, 64 (74.4%) reported an emotional trigger before symptom onset. Patients with a previous emotional trigger had a longer hospital stay (4.3 + 2.0 days vs. 3.0 + 1.4, p = 0.002) with no difference in in-hospital complications (32.8% vs. 13.6%, p = 0.069), with no difference in 30-day mortality, readmissions, or recurrence rate between the groups. Conclusions: Patients with TTS related to an emotional trigger may represent a different population from patients without a preceding trigger by having more symptomatic disease and longer hospital stay, yet with no difference in the 30-day outcomes.
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spelling pubmed-97874632022-12-24 The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter? Moady, Gassan Ali, Otman Sweid, Rania Atar, Shaul J Clin Med Article Background: Takotsubo syndrome (TTS) is a unique type of reversible cardiomyopathy that predominantly affects elderly women. The role of physical and emotional stress in the pathophysiology of TTS is well established. However, the association between preceding emotional triggers and clinical outcomes in stable patients has not yet been fully investigated. We aimed to investigate the association between emotional triggers before symptom onset and clinical outcomes in stable patients with TTS. Methods: This is a retrospective cohort study based on the data of patients with ICD-9 discharge diagnosis of TTS between 2017 and 2022. Patients were divided into two groups: with and without obvious emotional trigger before symptom onset. Demographic, laboratory, echocardiographic, and clinical outcomes were obtained and compared between the two groups. Results: We included 86 patients (93% were women, mean age 68.8 ± 12.3 years). Of them, 64 (74.4%) reported an emotional trigger before symptom onset. Patients with a previous emotional trigger had a longer hospital stay (4.3 + 2.0 days vs. 3.0 + 1.4, p = 0.002) with no difference in in-hospital complications (32.8% vs. 13.6%, p = 0.069), with no difference in 30-day mortality, readmissions, or recurrence rate between the groups. Conclusions: Patients with TTS related to an emotional trigger may represent a different population from patients without a preceding trigger by having more symptomatic disease and longer hospital stay, yet with no difference in the 30-day outcomes. MDPI 2022-12-09 /pmc/articles/PMC9787463/ /pubmed/36555921 http://dx.doi.org/10.3390/jcm11247304 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moady, Gassan
Ali, Otman
Sweid, Rania
Atar, Shaul
The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter?
title The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter?
title_full The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter?
title_fullStr The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter?
title_full_unstemmed The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter?
title_short The Role of Stress in Stable Patients with Takotsubo Syndrome—Does the Trigger Matter?
title_sort role of stress in stable patients with takotsubo syndrome—does the trigger matter?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787463/
https://www.ncbi.nlm.nih.gov/pubmed/36555921
http://dx.doi.org/10.3390/jcm11247304
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