A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline

Sibiriline is a novel drug inhibiting receptor-interacting protein 1 kinase (RIPK1) and necroptosis, a regulated form of cell death involved in several disease models. In this study, we aimed to investigate the metabolic fate of sibiriline in a cross-sectional manner using an in silico prediction, c...

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Detalles Bibliográficos
Autores principales: Pelletier, Romain, Gicquel, Thomas, Simoes Eugenio, Mélanie, Ferron, Pierre-Jean, Morel, Isabelle, Delehouzé, Claire, Dimanche-Boitrel, Marie-Thérèse, Rousselot, Morgane, Le Daré, Brendan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787481/
https://www.ncbi.nlm.nih.gov/pubmed/36559159
http://dx.doi.org/10.3390/pharmaceutics14122665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787481/
https://www.ncbi.nlm.nih.gov/pubmed/36559159
http://dx.doi.org/10.3390/pharmaceutics14122665

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