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Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana

During the Chikungunya epidemic in the Caribbean and Latin America, pregnant women were affected by the virus in French Guiana. The question of the impact of the virus on pregnancy was raised because of the lack of scientific consensus and published data in the region. Thus, during the Chikungunya o...

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Autores principales: Basurko, Célia, Hcini, Najeh, Demar, Magalie, Abboud, Philippe, Nacher, Mathieu, Carles, Gabriel, Lambert, Véronique, Matheus, Séverine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787529/
https://www.ncbi.nlm.nih.gov/pubmed/36560712
http://dx.doi.org/10.3390/v14122705
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author Basurko, Célia
Hcini, Najeh
Demar, Magalie
Abboud, Philippe
Nacher, Mathieu
Carles, Gabriel
Lambert, Véronique
Matheus, Séverine
author_facet Basurko, Célia
Hcini, Najeh
Demar, Magalie
Abboud, Philippe
Nacher, Mathieu
Carles, Gabriel
Lambert, Véronique
Matheus, Séverine
author_sort Basurko, Célia
collection PubMed
description During the Chikungunya epidemic in the Caribbean and Latin America, pregnant women were affected by the virus in French Guiana. The question of the impact of the virus on pregnancy was raised because of the lack of scientific consensus and published data in the region. Thus, during the Chikungunya outbreak in French Guiana, a comparative study was set up using a cohort of pregnant women. The objective was to compare pregnancy and neonatal outcomes between pregnant women with Chikungunya virus (CHIKV) infection and pregnant women without CHIKV. Of 653 mothers included in the cohort, 246 mothers were included in the case-control study: 73 had CHIKV fever during pregnancy and 173 had neither fever nor CHIKV during pregnancy. The study did not observe any severe clinical presentation of CHIKV in the participating women. There were no intensive care unit admissions. In addition, the study showed no significant difference between the two groups with regard to pregnancy complications. However, the results showed a potential excess risk of neonatal ICU admission of the newborn when the maternal infection occurred within 7 days before delivery. These results suggest that special attention should be paid to neonates whose mothers were infected with CHIKV shortly before delivery.
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spelling pubmed-97875292022-12-24 Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana Basurko, Célia Hcini, Najeh Demar, Magalie Abboud, Philippe Nacher, Mathieu Carles, Gabriel Lambert, Véronique Matheus, Séverine Viruses Article During the Chikungunya epidemic in the Caribbean and Latin America, pregnant women were affected by the virus in French Guiana. The question of the impact of the virus on pregnancy was raised because of the lack of scientific consensus and published data in the region. Thus, during the Chikungunya outbreak in French Guiana, a comparative study was set up using a cohort of pregnant women. The objective was to compare pregnancy and neonatal outcomes between pregnant women with Chikungunya virus (CHIKV) infection and pregnant women without CHIKV. Of 653 mothers included in the cohort, 246 mothers were included in the case-control study: 73 had CHIKV fever during pregnancy and 173 had neither fever nor CHIKV during pregnancy. The study did not observe any severe clinical presentation of CHIKV in the participating women. There were no intensive care unit admissions. In addition, the study showed no significant difference between the two groups with regard to pregnancy complications. However, the results showed a potential excess risk of neonatal ICU admission of the newborn when the maternal infection occurred within 7 days before delivery. These results suggest that special attention should be paid to neonates whose mothers were infected with CHIKV shortly before delivery. MDPI 2022-12-02 /pmc/articles/PMC9787529/ /pubmed/36560712 http://dx.doi.org/10.3390/v14122705 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Basurko, Célia
Hcini, Najeh
Demar, Magalie
Abboud, Philippe
Nacher, Mathieu
Carles, Gabriel
Lambert, Véronique
Matheus, Séverine
Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana
title Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana
title_full Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana
title_fullStr Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana
title_full_unstemmed Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana
title_short Symptomatic Chikungunya Virus Infection and Pregnancy Outcomes: A Nested Case-Control Study in French Guiana
title_sort symptomatic chikungunya virus infection and pregnancy outcomes: a nested case-control study in french guiana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787529/
https://www.ncbi.nlm.nih.gov/pubmed/36560712
http://dx.doi.org/10.3390/v14122705
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