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Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study
BACKGROUND: The association between maternal antibiotic exposure during pregnancy and childhood obesity is still unclear. OBJECTIVES: The study aimed to evaluate the association between prenatal exposure to antibiotics and obesity at age 3 years using data from a large Japanese birth cohort. METHODS...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787574/ https://www.ncbi.nlm.nih.gov/pubmed/35751177 http://dx.doi.org/10.1111/ijpo.12956 |
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author | Sakurai, Kenichi Yamamoto, Midori Eguchi, Akifumi Takatani, Rieko Watanabe, Masahiro Mori, Chisato |
author_facet | Sakurai, Kenichi Yamamoto, Midori Eguchi, Akifumi Takatani, Rieko Watanabe, Masahiro Mori, Chisato |
author_sort | Sakurai, Kenichi |
collection | PubMed |
description | BACKGROUND: The association between maternal antibiotic exposure during pregnancy and childhood obesity is still unclear. OBJECTIVES: The study aimed to evaluate the association between prenatal exposure to antibiotics and obesity at age 3 years using data from a large Japanese birth cohort. METHODS: The Japan Environment and Children's Study is a nationwide birth cohort study. In this study, singleton vaginal full‐term births were included. Obesity was defined as body mass index ≥95th percentile according to child growth standards. Prenatal antibiotic exposure was defined as antimicrobial agent use during pregnancy and was collected from maternal interviews and medical record transcripts. Logistic regression analysis was performed to evaluate the association of prenatal antibiotic exposure with child obesity at 3 years. RESULTS: In the crude and adjusted models with all children, maternal antibiotic exposure during pregnancy showed a marginal relationship with child obesity at 3 years. In the analyses according to exposure period and sex, exposure to antibiotics during the second/third trimester was significantly associated with obesity at the age of 3 years in female infants, but not in male infants, although the exposure during the first trimester was not in both sexes. CONCLUSION: Maternal antibiotic exposure during mid/late pregnancy may result in child obesity. |
format | Online Article Text |
id | pubmed-9787574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97875742022-12-27 Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study Sakurai, Kenichi Yamamoto, Midori Eguchi, Akifumi Takatani, Rieko Watanabe, Masahiro Mori, Chisato Pediatr Obes Original Research BACKGROUND: The association between maternal antibiotic exposure during pregnancy and childhood obesity is still unclear. OBJECTIVES: The study aimed to evaluate the association between prenatal exposure to antibiotics and obesity at age 3 years using data from a large Japanese birth cohort. METHODS: The Japan Environment and Children's Study is a nationwide birth cohort study. In this study, singleton vaginal full‐term births were included. Obesity was defined as body mass index ≥95th percentile according to child growth standards. Prenatal antibiotic exposure was defined as antimicrobial agent use during pregnancy and was collected from maternal interviews and medical record transcripts. Logistic regression analysis was performed to evaluate the association of prenatal antibiotic exposure with child obesity at 3 years. RESULTS: In the crude and adjusted models with all children, maternal antibiotic exposure during pregnancy showed a marginal relationship with child obesity at 3 years. In the analyses according to exposure period and sex, exposure to antibiotics during the second/third trimester was significantly associated with obesity at the age of 3 years in female infants, but not in male infants, although the exposure during the first trimester was not in both sexes. CONCLUSION: Maternal antibiotic exposure during mid/late pregnancy may result in child obesity. John Wiley & Sons, Inc. 2022-06-24 2022-11 /pmc/articles/PMC9787574/ /pubmed/35751177 http://dx.doi.org/10.1111/ijpo.12956 Text en © 2022 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Sakurai, Kenichi Yamamoto, Midori Eguchi, Akifumi Takatani, Rieko Watanabe, Masahiro Mori, Chisato Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study |
title | Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study |
title_full | Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study |
title_fullStr | Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study |
title_full_unstemmed | Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study |
title_short | Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study |
title_sort | association between maternal antibiotic exposure during pregnancy and childhood obesity in the japan environment and children's study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787574/ https://www.ncbi.nlm.nih.gov/pubmed/35751177 http://dx.doi.org/10.1111/ijpo.12956 |
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