Cargando…

Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens

Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University...

Descripción completa

Detalles Bibliográficos
Autores principales: Schizas, Dimitrios, Mylonas, Konstantinos S., Syllaios, Athanasios, Kapetanakis, Emmanouil I., Hasemaki, Natasha, Ntomi, Vasileia, Michalinos, Adamantios, Theochari, Nikoletta A., Theochari, Christina A., Krivan, Sylvia, Mpoura, Maria, Bakopoulos, Anargyros, Karavokyros, Ioannis, Liakakos, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787625/
https://www.ncbi.nlm.nih.gov/pubmed/36556994
http://dx.doi.org/10.3390/medicina58121792
Descripción
Sumario:Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University of Athens. Methods: The enrollment period was from June 2003 to September 2018. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Cox proportional hazard models were constructed to identify variables independently associated with time-to-event outcomes. Results: A total of 205 patients were analyzed. R0 resection was achieved in 183 (89.3%) patients and was more likely to occur following neoadjuvant chemotherapy (p = 0.008). Recurrence developed in 46.6% of our cohort and the median disease-free survival was 31.2 months. On multivariate analysis, only staging (HR = 2.15; 95% CI: 1.06–4.36) was independently associated with increased risk of recurrence. All-cause mortality was 57.2% and the median time of death was 40.9 months. On multivariate regression, staging (HR: 1.35; 95% CI: 1.11–1.65) and recurrence (HR: 2.87; 95% CI: 1.32–6.22) predicted inferior prognosis. Conclusions: Gastrectomy at the University of Athens has yielded favorable outcomes for patients with GEJ cancer.