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Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens

Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University...

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Autores principales: Schizas, Dimitrios, Mylonas, Konstantinos S., Syllaios, Athanasios, Kapetanakis, Emmanouil I., Hasemaki, Natasha, Ntomi, Vasileia, Michalinos, Adamantios, Theochari, Nikoletta A., Theochari, Christina A., Krivan, Sylvia, Mpoura, Maria, Bakopoulos, Anargyros, Karavokyros, Ioannis, Liakakos, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787625/
https://www.ncbi.nlm.nih.gov/pubmed/36556994
http://dx.doi.org/10.3390/medicina58121792
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author Schizas, Dimitrios
Mylonas, Konstantinos S.
Syllaios, Athanasios
Kapetanakis, Emmanouil I.
Hasemaki, Natasha
Ntomi, Vasileia
Michalinos, Adamantios
Theochari, Nikoletta A.
Theochari, Christina A.
Krivan, Sylvia
Mpoura, Maria
Bakopoulos, Anargyros
Karavokyros, Ioannis
Liakakos, Theodoros
author_facet Schizas, Dimitrios
Mylonas, Konstantinos S.
Syllaios, Athanasios
Kapetanakis, Emmanouil I.
Hasemaki, Natasha
Ntomi, Vasileia
Michalinos, Adamantios
Theochari, Nikoletta A.
Theochari, Christina A.
Krivan, Sylvia
Mpoura, Maria
Bakopoulos, Anargyros
Karavokyros, Ioannis
Liakakos, Theodoros
author_sort Schizas, Dimitrios
collection PubMed
description Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University of Athens. Methods: The enrollment period was from June 2003 to September 2018. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Cox proportional hazard models were constructed to identify variables independently associated with time-to-event outcomes. Results: A total of 205 patients were analyzed. R0 resection was achieved in 183 (89.3%) patients and was more likely to occur following neoadjuvant chemotherapy (p = 0.008). Recurrence developed in 46.6% of our cohort and the median disease-free survival was 31.2 months. On multivariate analysis, only staging (HR = 2.15; 95% CI: 1.06–4.36) was independently associated with increased risk of recurrence. All-cause mortality was 57.2% and the median time of death was 40.9 months. On multivariate regression, staging (HR: 1.35; 95% CI: 1.11–1.65) and recurrence (HR: 2.87; 95% CI: 1.32–6.22) predicted inferior prognosis. Conclusions: Gastrectomy at the University of Athens has yielded favorable outcomes for patients with GEJ cancer.
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spelling pubmed-97876252022-12-24 Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens Schizas, Dimitrios Mylonas, Konstantinos S. Syllaios, Athanasios Kapetanakis, Emmanouil I. Hasemaki, Natasha Ntomi, Vasileia Michalinos, Adamantios Theochari, Nikoletta A. Theochari, Christina A. Krivan, Sylvia Mpoura, Maria Bakopoulos, Anargyros Karavokyros, Ioannis Liakakos, Theodoros Medicina (Kaunas) Article Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University of Athens. Methods: The enrollment period was from June 2003 to September 2018. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Cox proportional hazard models were constructed to identify variables independently associated with time-to-event outcomes. Results: A total of 205 patients were analyzed. R0 resection was achieved in 183 (89.3%) patients and was more likely to occur following neoadjuvant chemotherapy (p = 0.008). Recurrence developed in 46.6% of our cohort and the median disease-free survival was 31.2 months. On multivariate analysis, only staging (HR = 2.15; 95% CI: 1.06–4.36) was independently associated with increased risk of recurrence. All-cause mortality was 57.2% and the median time of death was 40.9 months. On multivariate regression, staging (HR: 1.35; 95% CI: 1.11–1.65) and recurrence (HR: 2.87; 95% CI: 1.32–6.22) predicted inferior prognosis. Conclusions: Gastrectomy at the University of Athens has yielded favorable outcomes for patients with GEJ cancer. MDPI 2022-12-05 /pmc/articles/PMC9787625/ /pubmed/36556994 http://dx.doi.org/10.3390/medicina58121792 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schizas, Dimitrios
Mylonas, Konstantinos S.
Syllaios, Athanasios
Kapetanakis, Emmanouil I.
Hasemaki, Natasha
Ntomi, Vasileia
Michalinos, Adamantios
Theochari, Nikoletta A.
Theochari, Christina A.
Krivan, Sylvia
Mpoura, Maria
Bakopoulos, Anargyros
Karavokyros, Ioannis
Liakakos, Theodoros
Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens
title Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens
title_full Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens
title_fullStr Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens
title_full_unstemmed Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens
title_short Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens
title_sort gastrectomy for cancer: a 15-year analysis of real-world data from the university of athens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787625/
https://www.ncbi.nlm.nih.gov/pubmed/36556994
http://dx.doi.org/10.3390/medicina58121792
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