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Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens
Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787625/ https://www.ncbi.nlm.nih.gov/pubmed/36556994 http://dx.doi.org/10.3390/medicina58121792 |
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author | Schizas, Dimitrios Mylonas, Konstantinos S. Syllaios, Athanasios Kapetanakis, Emmanouil I. Hasemaki, Natasha Ntomi, Vasileia Michalinos, Adamantios Theochari, Nikoletta A. Theochari, Christina A. Krivan, Sylvia Mpoura, Maria Bakopoulos, Anargyros Karavokyros, Ioannis Liakakos, Theodoros |
author_facet | Schizas, Dimitrios Mylonas, Konstantinos S. Syllaios, Athanasios Kapetanakis, Emmanouil I. Hasemaki, Natasha Ntomi, Vasileia Michalinos, Adamantios Theochari, Nikoletta A. Theochari, Christina A. Krivan, Sylvia Mpoura, Maria Bakopoulos, Anargyros Karavokyros, Ioannis Liakakos, Theodoros |
author_sort | Schizas, Dimitrios |
collection | PubMed |
description | Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University of Athens. Methods: The enrollment period was from June 2003 to September 2018. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Cox proportional hazard models were constructed to identify variables independently associated with time-to-event outcomes. Results: A total of 205 patients were analyzed. R0 resection was achieved in 183 (89.3%) patients and was more likely to occur following neoadjuvant chemotherapy (p = 0.008). Recurrence developed in 46.6% of our cohort and the median disease-free survival was 31.2 months. On multivariate analysis, only staging (HR = 2.15; 95% CI: 1.06–4.36) was independently associated with increased risk of recurrence. All-cause mortality was 57.2% and the median time of death was 40.9 months. On multivariate regression, staging (HR: 1.35; 95% CI: 1.11–1.65) and recurrence (HR: 2.87; 95% CI: 1.32–6.22) predicted inferior prognosis. Conclusions: Gastrectomy at the University of Athens has yielded favorable outcomes for patients with GEJ cancer. |
format | Online Article Text |
id | pubmed-9787625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97876252022-12-24 Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens Schizas, Dimitrios Mylonas, Konstantinos S. Syllaios, Athanasios Kapetanakis, Emmanouil I. Hasemaki, Natasha Ntomi, Vasileia Michalinos, Adamantios Theochari, Nikoletta A. Theochari, Christina A. Krivan, Sylvia Mpoura, Maria Bakopoulos, Anargyros Karavokyros, Ioannis Liakakos, Theodoros Medicina (Kaunas) Article Background and Objectives: Encouraging data have been reported from referral centers following gastrointestinal cancer surgery. Our goal was to retrospectively review patient outcomes following gastrectomy for gastric or gastroesophageal junction (GEJ) cancer at a high-volume unit of the University of Athens. Methods: The enrollment period was from June 2003 to September 2018. Disease-free survival (DFS) and overall survival (OS) were estimated using the Kaplan-Meier method. Cox proportional hazard models were constructed to identify variables independently associated with time-to-event outcomes. Results: A total of 205 patients were analyzed. R0 resection was achieved in 183 (89.3%) patients and was more likely to occur following neoadjuvant chemotherapy (p = 0.008). Recurrence developed in 46.6% of our cohort and the median disease-free survival was 31.2 months. On multivariate analysis, only staging (HR = 2.15; 95% CI: 1.06–4.36) was independently associated with increased risk of recurrence. All-cause mortality was 57.2% and the median time of death was 40.9 months. On multivariate regression, staging (HR: 1.35; 95% CI: 1.11–1.65) and recurrence (HR: 2.87; 95% CI: 1.32–6.22) predicted inferior prognosis. Conclusions: Gastrectomy at the University of Athens has yielded favorable outcomes for patients with GEJ cancer. MDPI 2022-12-05 /pmc/articles/PMC9787625/ /pubmed/36556994 http://dx.doi.org/10.3390/medicina58121792 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schizas, Dimitrios Mylonas, Konstantinos S. Syllaios, Athanasios Kapetanakis, Emmanouil I. Hasemaki, Natasha Ntomi, Vasileia Michalinos, Adamantios Theochari, Nikoletta A. Theochari, Christina A. Krivan, Sylvia Mpoura, Maria Bakopoulos, Anargyros Karavokyros, Ioannis Liakakos, Theodoros Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens |
title | Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens |
title_full | Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens |
title_fullStr | Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens |
title_full_unstemmed | Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens |
title_short | Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens |
title_sort | gastrectomy for cancer: a 15-year analysis of real-world data from the university of athens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787625/ https://www.ncbi.nlm.nih.gov/pubmed/36556994 http://dx.doi.org/10.3390/medicina58121792 |
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