Cargando…
A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving treatment for respiratory failure that may serve as a bridge to patient recovery or lung transplantation. In COVID-19, recovery is somewhat unpredictable and occasionally occurs after >100 days on VV-ECMO support. Thus, de...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787659/ https://www.ncbi.nlm.nih.gov/pubmed/36556249 http://dx.doi.org/10.3390/jpm12122028 |
_version_ | 1784858565240946688 |
---|---|
author | Naar, Jan Kruger, Andreas Vondrakova, Dagmar Janotka, Marek Kubele, Jan Lischke, Robert Kolarova, Milena Neuzil, Petr Ostadal, Petr |
author_facet | Naar, Jan Kruger, Andreas Vondrakova, Dagmar Janotka, Marek Kubele, Jan Lischke, Robert Kolarova, Milena Neuzil, Petr Ostadal, Petr |
author_sort | Naar, Jan |
collection | PubMed |
description | Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving treatment for respiratory failure that may serve as a bridge to patient recovery or lung transplantation. In COVID-19, recovery is somewhat unpredictable and occasionally occurs after >100 days on VV-ECMO support. Thus, determining therapy cessation may be difficult. We report the case of a 59-year-old male without specific risk factors admitted to a tertiary center for rapidly progressive respiratory failure due to severe COVID-19, despite aggressive mechanical ventilatory support. Immediate insertion of VV-ECMO was associated with prompt resolution of hypoxemia and hypercapnia; however, all therapeutic efforts to wean the patient from VV-ECMO failed. During the prolonged hospitalization on VV-ECMO, sepsis was the most life-threatening complication. The patient overcame roughly 40 superinfections, predominantly affecting the respiratory tract, and spent 183 days on antimicrobial treatment. Although the function of other organ systems was generally stable, gradually progressive right ventricular dysfunction due to precapillary pulmonary hypertension required increasing doses of inotropes. A successful lung transplantation was performed after 207 days of VV-ECMO support. The present case provides evidence for prolonged VV-ECMO therapy as a bridge to lung transplantation in severe COVID-19 despite numerous, predominantly infectious complications. |
format | Online Article Text |
id | pubmed-9787659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97876592022-12-24 A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report Naar, Jan Kruger, Andreas Vondrakova, Dagmar Janotka, Marek Kubele, Jan Lischke, Robert Kolarova, Milena Neuzil, Petr Ostadal, Petr J Pers Med Case Report Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-saving treatment for respiratory failure that may serve as a bridge to patient recovery or lung transplantation. In COVID-19, recovery is somewhat unpredictable and occasionally occurs after >100 days on VV-ECMO support. Thus, determining therapy cessation may be difficult. We report the case of a 59-year-old male without specific risk factors admitted to a tertiary center for rapidly progressive respiratory failure due to severe COVID-19, despite aggressive mechanical ventilatory support. Immediate insertion of VV-ECMO was associated with prompt resolution of hypoxemia and hypercapnia; however, all therapeutic efforts to wean the patient from VV-ECMO failed. During the prolonged hospitalization on VV-ECMO, sepsis was the most life-threatening complication. The patient overcame roughly 40 superinfections, predominantly affecting the respiratory tract, and spent 183 days on antimicrobial treatment. Although the function of other organ systems was generally stable, gradually progressive right ventricular dysfunction due to precapillary pulmonary hypertension required increasing doses of inotropes. A successful lung transplantation was performed after 207 days of VV-ECMO support. The present case provides evidence for prolonged VV-ECMO therapy as a bridge to lung transplantation in severe COVID-19 despite numerous, predominantly infectious complications. MDPI 2022-12-07 /pmc/articles/PMC9787659/ /pubmed/36556249 http://dx.doi.org/10.3390/jpm12122028 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Naar, Jan Kruger, Andreas Vondrakova, Dagmar Janotka, Marek Kubele, Jan Lischke, Robert Kolarova, Milena Neuzil, Petr Ostadal, Petr A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report |
title | A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report |
title_full | A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report |
title_fullStr | A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report |
title_full_unstemmed | A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report |
title_short | A Total of 207 Days of Veno-Venous Extracorporeal Membrane Oxygenation Support for Severe COVID-19 Prior to Successful Lung Transplantation: A Case Report |
title_sort | total of 207 days of veno-venous extracorporeal membrane oxygenation support for severe covid-19 prior to successful lung transplantation: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787659/ https://www.ncbi.nlm.nih.gov/pubmed/36556249 http://dx.doi.org/10.3390/jpm12122028 |
work_keys_str_mv | AT naarjan atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT krugerandreas atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT vondrakovadagmar atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT janotkamarek atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT kubelejan atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT lischkerobert atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT kolarovamilena atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT neuzilpetr atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT ostadalpetr atotalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT naarjan totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT krugerandreas totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT vondrakovadagmar totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT janotkamarek totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT kubelejan totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT lischkerobert totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT kolarovamilena totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT neuzilpetr totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport AT ostadalpetr totalof207daysofvenovenousextracorporealmembraneoxygenationsupportforseverecovid19priortosuccessfullungtransplantationacasereport |