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Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study

Systemic Sclerosis (SSc) is an autoimmune disorder characterized by organ and tissue fibrosis in which the incidence of atherosclerosis and cardiovascular events is increased, although the exact underlying mechanism remains unclear. Arterial stiffness is a marker of vascular damage that can predict...

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Autores principales: Iaquinta, Francesco Salvatore, Grosso, Roberta, Di Napoli, Stefania, Cassano, Velia, Naty, Saverio, Armentaro, Giuseppe, Massimino, Mattia, Condoleo, Valentino, Barbara, Keti, Crescibene, Daniele, Caroleo, Benedetto, Miceli, Sofia, Sciacqua, Angela, Grembiale, Rosa Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787664/
https://www.ncbi.nlm.nih.gov/pubmed/36556173
http://dx.doi.org/10.3390/jpm12121952
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author Iaquinta, Francesco Salvatore
Grosso, Roberta
Di Napoli, Stefania
Cassano, Velia
Naty, Saverio
Armentaro, Giuseppe
Massimino, Mattia
Condoleo, Valentino
Barbara, Keti
Crescibene, Daniele
Caroleo, Benedetto
Miceli, Sofia
Sciacqua, Angela
Grembiale, Rosa Daniela
author_facet Iaquinta, Francesco Salvatore
Grosso, Roberta
Di Napoli, Stefania
Cassano, Velia
Naty, Saverio
Armentaro, Giuseppe
Massimino, Mattia
Condoleo, Valentino
Barbara, Keti
Crescibene, Daniele
Caroleo, Benedetto
Miceli, Sofia
Sciacqua, Angela
Grembiale, Rosa Daniela
author_sort Iaquinta, Francesco Salvatore
collection PubMed
description Systemic Sclerosis (SSc) is an autoimmune disorder characterized by organ and tissue fibrosis in which the incidence of atherosclerosis and cardiovascular events is increased, although the exact underlying mechanism remains unclear. Arterial stiffness is a marker of vascular damage that can predict cardiovascular events; therefore, this study aimed to assess the augmentation index (AIx) and pulse wave velocity (PWV), markers of stiffness, in a Systemic Sclerosis population and to detect potentially associated variables. Fourteen female Systemic Sclerosis patients and 14 age- and sex-matched controls were enrolled. Demographic, anthropometric, sero-hematological parameters and disease characteristics were collected for each participant. Arterial stiffness was evaluated using an applanation tonometry system. No differences were found between groups, except for BMI, fasting blood glucose, red blood cells count, hemoglobin, and treatment. Patients had increased augmentation index than the controls (p = 0.008). PWV was significantly decreased in SSc patients compared with the controls (p = 0.007). PWV was correlated with age (r = 0.462; p = 0.048) and BMI (r = 0.458; p = 0.050). Finally, patients with no specific auto-antibody pattern had greater AIx than those expressing anticentromere antibodies. Our study demonstrated that SSc patients had greater AIx, but lower PWV than the controls. In addition, few variables were correlated to arterial stiffness. Further studies are necessary to validate these findings and to establish medication’s role in modifying cardiovascular risk.
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spelling pubmed-97876642022-12-24 Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study Iaquinta, Francesco Salvatore Grosso, Roberta Di Napoli, Stefania Cassano, Velia Naty, Saverio Armentaro, Giuseppe Massimino, Mattia Condoleo, Valentino Barbara, Keti Crescibene, Daniele Caroleo, Benedetto Miceli, Sofia Sciacqua, Angela Grembiale, Rosa Daniela J Pers Med Article Systemic Sclerosis (SSc) is an autoimmune disorder characterized by organ and tissue fibrosis in which the incidence of atherosclerosis and cardiovascular events is increased, although the exact underlying mechanism remains unclear. Arterial stiffness is a marker of vascular damage that can predict cardiovascular events; therefore, this study aimed to assess the augmentation index (AIx) and pulse wave velocity (PWV), markers of stiffness, in a Systemic Sclerosis population and to detect potentially associated variables. Fourteen female Systemic Sclerosis patients and 14 age- and sex-matched controls were enrolled. Demographic, anthropometric, sero-hematological parameters and disease characteristics were collected for each participant. Arterial stiffness was evaluated using an applanation tonometry system. No differences were found between groups, except for BMI, fasting blood glucose, red blood cells count, hemoglobin, and treatment. Patients had increased augmentation index than the controls (p = 0.008). PWV was significantly decreased in SSc patients compared with the controls (p = 0.007). PWV was correlated with age (r = 0.462; p = 0.048) and BMI (r = 0.458; p = 0.050). Finally, patients with no specific auto-antibody pattern had greater AIx than those expressing anticentromere antibodies. Our study demonstrated that SSc patients had greater AIx, but lower PWV than the controls. In addition, few variables were correlated to arterial stiffness. Further studies are necessary to validate these findings and to establish medication’s role in modifying cardiovascular risk. MDPI 2022-11-24 /pmc/articles/PMC9787664/ /pubmed/36556173 http://dx.doi.org/10.3390/jpm12121952 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iaquinta, Francesco Salvatore
Grosso, Roberta
Di Napoli, Stefania
Cassano, Velia
Naty, Saverio
Armentaro, Giuseppe
Massimino, Mattia
Condoleo, Valentino
Barbara, Keti
Crescibene, Daniele
Caroleo, Benedetto
Miceli, Sofia
Sciacqua, Angela
Grembiale, Rosa Daniela
Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study
title Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study
title_full Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study
title_fullStr Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study
title_full_unstemmed Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study
title_short Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study
title_sort decreased pulse wave velocity in a systemic sclerosis population: preliminary results from a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787664/
https://www.ncbi.nlm.nih.gov/pubmed/36556173
http://dx.doi.org/10.3390/jpm12121952
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