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Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease

While amyloid‐β (Aβ) plaques are considered a hallmark of Alzheimer's disease, clinical trials focused on targeting gamma secretase, an enzyme involved in aberrant Aβ peptide production, have not led to amelioration of AD symptoms or synaptic dysregulation. Screening strategies based on mechani...

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Detalles Bibliográficos
Autores principales:	Caldwell, Andrew B., Liu, Qing, Zhang, Can, Schroth, Gary P., Galasko, Douglas R., Rynearson, Kevin D., Tanzi, Rudolph E., Yuan, Shauna H., Wagner, Steven L., Subramaniam, Shankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Featured Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787711/ https://www.ncbi.nlm.nih.gov/pubmed/35084109 http://dx.doi.org/10.1002/alz.12553

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