Cargando…

Micellar Curcumin: Pharmacokinetics and Effects on Inflammation Markers and PCSK‐9 Concentrations in Healthy Subjects in a Double‐Blind, Randomized, Active‐Controlled, Crossover Trial

Scope: Preclinical models have demonstrated the anti‐inflammatory and lipid‐lowering effects of curcumin. Innovative formulations have been developed to overcome the poor bioavailability of native curcumin. The study hypothesizes that the bioavailability of micellar curcumin is superior to native cu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grafeneder, Juergen, Derhaschnig, Ulla, Eskandary, Farsad, Buchtele, Nina, Sus, Nadine, Frank, Jan, Jilma, Bernd, Schoergenhofer, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787856/ https://www.ncbi.nlm.nih.gov/pubmed/36101515 http://dx.doi.org/10.1002/mnfr.202200139

Ejemplares similares

Defibrotide enhances fibrinolysis in human endotoxemia – a randomized, double blind, crossover trial in healthy volunteers
por: Schoergenhofer, Christian, et al.
Publicado: (2019)

Safety, tolerability, pharmacokinetics and pharmacodynamics of parenterally administered dutogliptin: A prospective dose‐escalating trial
por: Buchtele, Nina, et al.
Publicado: (2020)

The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin
por: Kovacevic, Katarina D., et al.
Publicado: (2020)

Low PCSK-9 levels Are Associated with Favorable Neurologic Function after Resuscitation from out of Hospital Cardiac Arrest
por: Merrelaar, Anne, et al.
Publicado: (2020)

Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers
por: Hobl, Eva-Luise, et al.
Publicado: (2015)

Multi-phasic life-threatening anaphylaxis refractory to epinephrine managed by extracorporeal membrane oxygenation (ECMO): A case report
por: Grafeneder, Juergen, et al.
Publicado: (2022)

Corticosteroid Treatment Prevents Lipopolysaccharide-Induced Increase of ACE2 and Reduces Fibrin Degradation Products in Bronchoalveolar Lavage Fluid
por: Reindl-Schwaighofer, Roman, et al.
Publicado: (2022)

The use of frozen plasma samples in thromboelastometry
por: Schoergenhofer, Christian, et al.
Publicado: (2017)

Dissociation between systemic and pulmonary anti‐inflammatory effects of dexamethasone in humans
por: Bartko, Johann, et al.
Publicado: (2016)

Chikungunya vaccines in development
por: Schwameis, Michael, et al.
Publicado: (2015)

Change of Hemoglobin Levels in the Early Post-cardiac Arrest Phase Is Associated With Outcome
por: Schriefl, Christoph, et al.
Publicado: (2021)

Advanced pharmacodynamics of cangrelor in healthy volunteers: a dose-finding, open-label, pilot trial
por: Gelbenegger, Georg, et al.
Publicado: (2022)

Cytotoxic, Genotoxic and Senolytic Potential of Native and Micellar Curcumin
por: Beltzig, Lea, et al.
Publicado: (2021)

Single, very low rituximab doses in healthy volunteers - a pilot and a randomized trial: implications for dosing and biosimilarity testing
por: Schoergenhofer, Christian, et al.
Publicado: (2018)

Blood urea nitrogen kinetics in the early postcardiac arrest phase are associated with clinical outcome: A retrospective cohort study
por: Schriefl, Christoph, et al.
Publicado: (2022)

Angiotensin II for the treatment of vasodilatory shock: enough data to consider angiotensin II safe?
por: Buchtele, Nina, et al.
Publicado: (2018)

The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial
por: Kovacevic, Katarina D., et al.
Publicado: (2021)

Combined integrated protocol/basket trial design for a first-in-human trial
por: Derhaschnig, Ulla, et al.
Publicado: (2016)

Pharmacokinetics of a Novel Anagrelide Extended‐Release Formulation in Healthy Subjects: Food Intake and Comparison With a Reference Product
por: Petrides, Petro E., et al.
Publicado: (2017)

Colistin dampens fibrinolysis and endothelial activation during endotoxaemia: A randomised, double blind trial
por: Schoergenhofer, Christian, et al.
Publicado: (2017)

Human diamine oxidase is readily released from activated neutrophils ex vivo and in vivo but is rarely elevated in bacteremic patients
por: Boehm, Thomas, et al.
Publicado: (2020)

Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery
por: Wijiani, Nina, et al.
Publicado: (2020)

Serum and Lung Pharmacokinetics of ASN100, a Monoclonal Antibody Combination for the Prevention and Treatment of Staphylococcus aureus Pneumonia
por: Magyarics, Zoltan, et al.
Publicado: (2017)

Author Correction: Admission C-reactive protein concentrations are associated with unfavourable neurological outcome after out-of-hospital cardiac arrest
por: Schriefl, Christoph, et al.
Publicado: (2021)

Admission C-reactive protein concentrations are associated with unfavourable neurological outcome after out-of-hospital cardiac arrest
por: Schriefl, Christoph, et al.
Publicado: (2021)

Folate-Targeted Curcumin-Encapsulated Micellar Nanosystem for Chemotherapy and Curcumin-Mediated Photodynamic Therapy
por: Lin, Yun Hsuan, et al.
Publicado: (2020)

The von Willebrand factor–binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A
por: Ay, Cihan, et al.
Publicado: (2023)

Dexamethasone inhibits endotoxin‐induced coagulopathy in human lungs
por: Bartko, J., et al.
Publicado: (2016)

Increased Fibrinolysis as a Specific Marker of Poor Outcome After Cardiac Arrest
por: Buchtele, Nina, et al.
Publicado: (2018)

Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence
por: Buchtele, Nina, et al.
Publicado: (2018)

Performance of a Qualitative Point-of-Care Strip Test to Detect DOAC Exposure at the Emergency Department: A Cohort-Type Cross-Sectional Diagnostic Accuracy Study
por: Merrelaar, Anne E., et al.
Publicado: (2022)

Evaluation of anti-inflammatory and anti-adhesive effects of heparins in human endotoxemia
por: Derhaschnig, U, et al.
Publicado: (2002)

Severe Hypernatraemic Dehydration and Unconsciousness in a Care-Dependent Inpatient Treated with Empagliflozin
por: Gelbenegger, Georg, et al.
Publicado: (2017)

Bridging the Missing Link with Emicizumab: A Bispecific Antibody for Treatment of Hemophilia A
por: Gelbenegger, Georg, et al.
Publicado: (2020)

Transepithelial Transport of Curcumin in Caco-2 Cells Is significantly Enhanced by Micellar Solubilisation
por: Frank, Jan, et al.
Publicado: (2016)

Use of Micellar Delivery Systems to Enhance Curcumin’s Stability and Microbial Photoinactivation Capacity
por: Ryu, Victor, et al.
Publicado: (2021)

LUBAC and ABIN-1 Modulate TRAIL-Based NF-κB Induction in Human Embryonic Kidney 293 Cells
por: Dorn, Sebastian, et al.
Publicado: (2018)

ABO-Incompatibility: Time to Challenge the Paradigm of Equivalence in Live-Donor Kidney Transplantation?
por: Eskandary, Farsad, et al.
Publicado: (2022)

A complex micellar system co-delivering curcumin with doxorubicin against cardiotoxicity and tumor growth
por: Zhang, Di, et al.
Publicado: (2018)

Mechanism of the Micellar Solubilization of Curcumin by Mixed Surfactants of SDS and Brij35 via NMR Spectroscopy
por: Zhan, Xiao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_stf4th5e1rtr3lhik6c5f0aj1v