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Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy

(1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrol...

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Autores principales: Lin, Chin-Yu, Chung, Fa-Po, Nwe, Nwe, Hsieh, Yu-Cheng, Li, Cheng-Hung, Lin, Yenn-Jiang, Chang, Shih-Lin, Lo, Li-Wei, Hu, Yu-Feng, Tuan, Ta-Chuan, Chao, Tze-Fan, Liao, Jo-Nan, Chang, Ting-Yung, Kuo, Ling, Wu, Cheng-I, Liu, Chih-Min, Liu, Shin-Huei, Cheng, Wen-Han, Chen, Shih-Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787968/
https://www.ncbi.nlm.nih.gov/pubmed/36555882
http://dx.doi.org/10.3390/jcm11247265
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author Lin, Chin-Yu
Chung, Fa-Po
Nwe, Nwe
Hsieh, Yu-Cheng
Li, Cheng-Hung
Lin, Yenn-Jiang
Chang, Shih-Lin
Lo, Li-Wei
Hu, Yu-Feng
Tuan, Ta-Chuan
Chao, Tze-Fan
Liao, Jo-Nan
Chang, Ting-Yung
Kuo, Ling
Wu, Cheng-I
Liu, Chih-Min
Liu, Shin-Huei
Cheng, Wen-Han
Chen, Shih-Ann
author_facet Lin, Chin-Yu
Chung, Fa-Po
Nwe, Nwe
Hsieh, Yu-Cheng
Li, Cheng-Hung
Lin, Yenn-Jiang
Chang, Shih-Lin
Lo, Li-Wei
Hu, Yu-Feng
Tuan, Ta-Chuan
Chao, Tze-Fan
Liao, Jo-Nan
Chang, Ting-Yung
Kuo, Ling
Wu, Cheng-I
Liu, Chih-Min
Liu, Shin-Huei
Cheng, Wen-Han
Chen, Shih-Ann
author_sort Lin, Chin-Yu
collection PubMed
description (1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT. In all patients, substrate modification was performed to achieve non-inducible VT. The patients were categorized into two groups according to whether they had used amiodarone before CA. Baseline and electrophysiological characteristics, substrate, and outcomes were compared. (3) Results: A total of 72 ARVC patients were studied, including 29 (40.3%) “off” amiodarone and 43 (56.7%) “on” amiodarone. The scar area was similar between the two groups. Patients “off” amiodarone had smaller endocardial and epicardial areas with abnormal electrograms. Twenty of 43 patients (47.5%) “on” amiodarone discontinued it within 3 months after CA. During a mean follow-up period of 43.2 ± 29.5 months, higher VT recurrence was observed in patients “on” amiodarone. Patients “on” amiodarone who discontinued amiodarone after CA had a lower recurrence than those without. (4) Conclusions: Patients with ARVC “on” amiodarone before CA had distinct substrate characteristics and worse ablation outcomes than patients “off” amiodarone, especially in those who had used amiodarone continuously.
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spelling pubmed-97879682022-12-24 Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy Lin, Chin-Yu Chung, Fa-Po Nwe, Nwe Hsieh, Yu-Cheng Li, Cheng-Hung Lin, Yenn-Jiang Chang, Shih-Lin Lo, Li-Wei Hu, Yu-Feng Tuan, Ta-Chuan Chao, Tze-Fan Liao, Jo-Nan Chang, Ting-Yung Kuo, Ling Wu, Cheng-I Liu, Chih-Min Liu, Shin-Huei Cheng, Wen-Han Chen, Shih-Ann J Clin Med Article (1) Background: Catheter ablation (CA) is an accepted treatment option for drug-refractory ventricular tachycardia (VT) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study investigates the effect of amiodarone on ablation outcomes in ARVC. (2) Methods: The study enrolled patients with ARVC undergoing CA of sustained VT. In all patients, substrate modification was performed to achieve non-inducible VT. The patients were categorized into two groups according to whether they had used amiodarone before CA. Baseline and electrophysiological characteristics, substrate, and outcomes were compared. (3) Results: A total of 72 ARVC patients were studied, including 29 (40.3%) “off” amiodarone and 43 (56.7%) “on” amiodarone. The scar area was similar between the two groups. Patients “off” amiodarone had smaller endocardial and epicardial areas with abnormal electrograms. Twenty of 43 patients (47.5%) “on” amiodarone discontinued it within 3 months after CA. During a mean follow-up period of 43.2 ± 29.5 months, higher VT recurrence was observed in patients “on” amiodarone. Patients “on” amiodarone who discontinued amiodarone after CA had a lower recurrence than those without. (4) Conclusions: Patients with ARVC “on” amiodarone before CA had distinct substrate characteristics and worse ablation outcomes than patients “off” amiodarone, especially in those who had used amiodarone continuously. MDPI 2022-12-07 /pmc/articles/PMC9787968/ /pubmed/36555882 http://dx.doi.org/10.3390/jcm11247265 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Chin-Yu
Chung, Fa-Po
Nwe, Nwe
Hsieh, Yu-Cheng
Li, Cheng-Hung
Lin, Yenn-Jiang
Chang, Shih-Lin
Lo, Li-Wei
Hu, Yu-Feng
Tuan, Ta-Chuan
Chao, Tze-Fan
Liao, Jo-Nan
Chang, Ting-Yung
Kuo, Ling
Wu, Cheng-I
Liu, Chih-Min
Liu, Shin-Huei
Cheng, Wen-Han
Chen, Shih-Ann
Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
title Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
title_full Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
title_fullStr Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
title_full_unstemmed Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
title_short Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
title_sort impact of amiodarone therapy on the ablation outcome of ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787968/
https://www.ncbi.nlm.nih.gov/pubmed/36555882
http://dx.doi.org/10.3390/jcm11247265
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