Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches

Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological consequences for infected infants and adults, there are still no approved drugs to treat ZIKV infection. In this study, we applied computational approaches to screen an in-house database of 77 natural and semi-synthetic...

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Detalles Bibliográficos
Autores principales: Ramos, Paulo Ricardo Pimenta da Silva, Mottin, Melina, Lima, Caroline Sprengel, Assis, Letícia R., de Oliveira, Ketllyn Zagato, Mesquita, Nathalya Cristina de Moraes Roso, Cassani, Natasha Marques, Santos, Igor Andrade, Borba, Joyce Villa Verde Bastos, Fiaia Costa, Vinícius Alexandre, Neves, Bruno Junior, Guido, Rafael Victorio Carvalho, Oliva, Glaucius, Jardim, Ana Carolina Gomes, Regasini, Luis Octávio, Andrade, Carolina Horta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788182/
https://www.ncbi.nlm.nih.gov/pubmed/36558945
http://dx.doi.org/10.3390/ph15121493

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