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No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial

SCOPE: Some dietary interventions with berry fruits, berry fruit extracts, and purified anthocyanins have been reported to beneficially alter lipoprotein profiles in hyperlipidemic participants. The major anthocyanins in human diets are glycosides of cyanidin and delphinidin, and structure can influ...

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Autores principales: Aboufarrag, Hassan, Hollands, Wendy J., Percival, Jasmine, Philo, Mark, Savva, George M., Kroon, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788215/
https://www.ncbi.nlm.nih.gov/pubmed/35385209
http://dx.doi.org/10.1002/mnfr.202101157
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author Aboufarrag, Hassan
Hollands, Wendy J.
Percival, Jasmine
Philo, Mark
Savva, George M.
Kroon, Paul A.
author_facet Aboufarrag, Hassan
Hollands, Wendy J.
Percival, Jasmine
Philo, Mark
Savva, George M.
Kroon, Paul A.
author_sort Aboufarrag, Hassan
collection PubMed
description SCOPE: Some dietary interventions with berry fruits, berry fruit extracts, and purified anthocyanins have been reported to beneficially alter lipoprotein profiles in hyperlipidemic participants. The major anthocyanins in human diets are glycosides of cyanidin and delphinidin, and structure can influence both absorption and bioactivity. The aim of this study is to determine the effects of two major types of anthocyanins on low‐density lipoprotein cholesterol and other cardiometabolic markers for cardiovascular disease (CVD) risk in hyperlipidemic individuals. METHODS AND RESULTS: Fifty‐two hyperlipidemic participants complete this randomized, placebo‐controlled, double‐blind, three arm crossover trial. Participants ingest capsules containing 320 mg of anthocyanins (bilberry trihydroxy‐type or black rice dihydroxy‐type) or placebo once daily for 28 days. Biomarkers of CVD risk are measured before and after the intervention period. Compared to the placebo, neither anthocyanin treatment significantly (p < 0.05) changes circulating levels of lipoproteins (total‐/high‐density lipoprotein (HDL)‐/low‐density lipoprotein (LDL)‐cholesterol, triglycerides, Apolipoprotein B (ApoB)), biomarkers of glycemic control (fasting glucose, fructosamine), biomarkers of HDL function (ApoA1, HDL3, paraoxonase‐1 (PON1) arylesterase, and lactonase activities), or plasma bile acids. CONCLUSIONS: These data do not support the notion that regular consumption of anthocyanins beneficially affects glycemic control or lipoprotein profiles or functions. It is possible the no effect observation is due to the relatively short duration of treatments.
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spelling pubmed-97882152022-12-28 No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial Aboufarrag, Hassan Hollands, Wendy J. Percival, Jasmine Philo, Mark Savva, George M. Kroon, Paul A. Mol Nutr Food Res Research Article SCOPE: Some dietary interventions with berry fruits, berry fruit extracts, and purified anthocyanins have been reported to beneficially alter lipoprotein profiles in hyperlipidemic participants. The major anthocyanins in human diets are glycosides of cyanidin and delphinidin, and structure can influence both absorption and bioactivity. The aim of this study is to determine the effects of two major types of anthocyanins on low‐density lipoprotein cholesterol and other cardiometabolic markers for cardiovascular disease (CVD) risk in hyperlipidemic individuals. METHODS AND RESULTS: Fifty‐two hyperlipidemic participants complete this randomized, placebo‐controlled, double‐blind, three arm crossover trial. Participants ingest capsules containing 320 mg of anthocyanins (bilberry trihydroxy‐type or black rice dihydroxy‐type) or placebo once daily for 28 days. Biomarkers of CVD risk are measured before and after the intervention period. Compared to the placebo, neither anthocyanin treatment significantly (p < 0.05) changes circulating levels of lipoproteins (total‐/high‐density lipoprotein (HDL)‐/low‐density lipoprotein (LDL)‐cholesterol, triglycerides, Apolipoprotein B (ApoB)), biomarkers of glycemic control (fasting glucose, fructosamine), biomarkers of HDL function (ApoA1, HDL3, paraoxonase‐1 (PON1) arylesterase, and lactonase activities), or plasma bile acids. CONCLUSIONS: These data do not support the notion that regular consumption of anthocyanins beneficially affects glycemic control or lipoprotein profiles or functions. It is possible the no effect observation is due to the relatively short duration of treatments. John Wiley and Sons Inc. 2022-04-26 2022-11 /pmc/articles/PMC9788215/ /pubmed/35385209 http://dx.doi.org/10.1002/mnfr.202101157 Text en © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aboufarrag, Hassan
Hollands, Wendy J.
Percival, Jasmine
Philo, Mark
Savva, George M.
Kroon, Paul A.
No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial
title No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial
title_full No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial
title_fullStr No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial
title_full_unstemmed No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial
title_short No Effect of Isolated Anthocyanins from Bilberry Fruit and Black Rice on LDL Cholesterol or other Biomarkers of Cardiovascular Disease in Adults with Elevated Cholesterol: A Randomized, Placebo‐Controlled, Cross‐Over Trial
title_sort no effect of isolated anthocyanins from bilberry fruit and black rice on ldl cholesterol or other biomarkers of cardiovascular disease in adults with elevated cholesterol: a randomized, placebo‐controlled, cross‐over trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788215/
https://www.ncbi.nlm.nih.gov/pubmed/35385209
http://dx.doi.org/10.1002/mnfr.202101157
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