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Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review

Wernicke encephalopathy (WE) is a well-known neurological condition caused by thiamine (vitamin B1) deficiency that occurs in both alcoholic and non-alcoholic populations. We aimed to report a case of a patient with WE who presented with dysphagia and dysphonia and later developed typical symptoms o...

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Autores principales: Cornea, Amalia, Lata, Irina, Simu, Mihaela, Rosca, Elena Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788281/
https://www.ncbi.nlm.nih.gov/pubmed/36558453
http://dx.doi.org/10.3390/nu14245294
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author Cornea, Amalia
Lata, Irina
Simu, Mihaela
Rosca, Elena Cecilia
author_facet Cornea, Amalia
Lata, Irina
Simu, Mihaela
Rosca, Elena Cecilia
author_sort Cornea, Amalia
collection PubMed
description Wernicke encephalopathy (WE) is a well-known neurological condition caused by thiamine (vitamin B1) deficiency that occurs in both alcoholic and non-alcoholic populations. We aimed to report a case of a patient with WE who presented with dysphagia and dysphonia and later developed typical symptoms of thiamine deficiency and to conduct a systematic review of the literature on this rare presentation of WE. We searched two databases (PubMed and Scopus) and included publications up to November 2022. We found 12 cases of WE and dysphagia, aged between 12 and 81 years; swallowing problems presented at the onset in nine patients (including the current case report). Our findings suggest that thiamine deficiency should be suspected in patients with dysphagia of unknown cause, even in the absence of alcohol abuse. In contrast to most WE patients, the majority of patients included in this review presented with dysphagia at the onset of their disease, even in the absence of the classic triad of cognitive impairment, ataxia, and oculomotor abnormalities, indicating that there could be varying susceptibilities to clinical manifestations of thiamine deficiency in different brain regions.
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spelling pubmed-97882812022-12-24 Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review Cornea, Amalia Lata, Irina Simu, Mihaela Rosca, Elena Cecilia Nutrients Systematic Review Wernicke encephalopathy (WE) is a well-known neurological condition caused by thiamine (vitamin B1) deficiency that occurs in both alcoholic and non-alcoholic populations. We aimed to report a case of a patient with WE who presented with dysphagia and dysphonia and later developed typical symptoms of thiamine deficiency and to conduct a systematic review of the literature on this rare presentation of WE. We searched two databases (PubMed and Scopus) and included publications up to November 2022. We found 12 cases of WE and dysphagia, aged between 12 and 81 years; swallowing problems presented at the onset in nine patients (including the current case report). Our findings suggest that thiamine deficiency should be suspected in patients with dysphagia of unknown cause, even in the absence of alcohol abuse. In contrast to most WE patients, the majority of patients included in this review presented with dysphagia at the onset of their disease, even in the absence of the classic triad of cognitive impairment, ataxia, and oculomotor abnormalities, indicating that there could be varying susceptibilities to clinical manifestations of thiamine deficiency in different brain regions. MDPI 2022-12-13 /pmc/articles/PMC9788281/ /pubmed/36558453 http://dx.doi.org/10.3390/nu14245294 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Cornea, Amalia
Lata, Irina
Simu, Mihaela
Rosca, Elena Cecilia
Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review
title Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review
title_full Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review
title_fullStr Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review
title_full_unstemmed Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review
title_short Wernicke Encephalopathy Presenting with Dysphagia: A Case Report and Systematic Literature Review
title_sort wernicke encephalopathy presenting with dysphagia: a case report and systematic literature review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788281/
https://www.ncbi.nlm.nih.gov/pubmed/36558453
http://dx.doi.org/10.3390/nu14245294
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