The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase

Previously, we reported that an HIV-1 variant containing Met-to-Ile change at codon 50 and Val-to-Ile mutation at codon 151 of integrase (IN), HIV(IN:M50I/V151I), was an impaired virus. Despite the mutations being in IN, the virus release was significantly suppressed (p < 0.0001) and the initiati...

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Detalles Bibliográficos
Autores principales: Imamichi, Tomozumi, Chen, Qian, Hao, Ming, Chang, Weizhong, Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788298/
https://www.ncbi.nlm.nih.gov/pubmed/36560691
http://dx.doi.org/10.3390/v14122687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788298/
https://www.ncbi.nlm.nih.gov/pubmed/36560691
http://dx.doi.org/10.3390/v14122687

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