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Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study

We aimed to describe adverse pregnancy outcomes among women who had symptomatic, RT-PCR-confirmed ZIKV infection and early childhood outcomes among their infants. We enrolled pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection in a prospective cohort study, and their infants in a prospe...

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Autores principales: Grant, Rebecca, Flechelles, Olivier, Elenga, Narcisse, Tressières, Benoît, Gaete, Stanie, Hebert, Jean-Christophe, Schaub, Bruno, Djossou, Felix, Mallard, Adeline, Delver, Lucetta, Ryan, Catherine, Funk, Anna L., Cabié, André, Fontanet, Arnaud, Hoen, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788325/
https://www.ncbi.nlm.nih.gov/pubmed/36560760
http://dx.doi.org/10.3390/v14122755
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author Grant, Rebecca
Flechelles, Olivier
Elenga, Narcisse
Tressières, Benoît
Gaete, Stanie
Hebert, Jean-Christophe
Schaub, Bruno
Djossou, Felix
Mallard, Adeline
Delver, Lucetta
Ryan, Catherine
Funk, Anna L.
Cabié, André
Fontanet, Arnaud
Hoen, Bruno
author_facet Grant, Rebecca
Flechelles, Olivier
Elenga, Narcisse
Tressières, Benoît
Gaete, Stanie
Hebert, Jean-Christophe
Schaub, Bruno
Djossou, Felix
Mallard, Adeline
Delver, Lucetta
Ryan, Catherine
Funk, Anna L.
Cabié, André
Fontanet, Arnaud
Hoen, Bruno
author_sort Grant, Rebecca
collection PubMed
description We aimed to describe adverse pregnancy outcomes among women who had symptomatic, RT-PCR-confirmed ZIKV infection and early childhood outcomes among their infants. We enrolled pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection in a prospective cohort study, and their infants in a prospective pediatric cohort study. We defined adverse pregnancy and early childhood outcomes based on selected neurologic, ophthalmologic, auditory, musculoskeletal, and anthropometric abnormalities. We used RT-PCR and serologic tests to determine the ZIKV infection status of the child. Between 10 March and 24 November 2016, we enrolled 546 pregnant women with RT-PCR-confirmed ZIKV infection. The overall risk of adverse pregnancy and early childhood outcomes possibly related to in utero ZIKV exposure was 15.7% (95% CI: 12.8–19.0), distributed as follows: 3.6% (95% CI: 2.3–5.6) severe sequelae or fatality; 2.7% (95% CI: 1.6–4.5) major abnormalities; 9.4% (95% CI:7.1–12.2) mild abnormalities. The risk of severe sequelae or fatality was higher when ZIKV infection occurred during the first trimester (7.0%), compared to the second (2.7%) or third trimester (1.4%) (p = 0.02). Among the infants for whom ZIKV infection status could be determined, the vertical transmission rate was 3.0% (5/167) (95% CI: 1.1–7.2). Among pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection, severe or major pregnancy or early childhood outcomes were present in 6.3% of fetuses and infants. Severe outcomes occurred more frequently in fetuses and infants whose mothers had been infected in the first trimester.
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spelling pubmed-97883252022-12-24 Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study Grant, Rebecca Flechelles, Olivier Elenga, Narcisse Tressières, Benoît Gaete, Stanie Hebert, Jean-Christophe Schaub, Bruno Djossou, Felix Mallard, Adeline Delver, Lucetta Ryan, Catherine Funk, Anna L. Cabié, André Fontanet, Arnaud Hoen, Bruno Viruses Article We aimed to describe adverse pregnancy outcomes among women who had symptomatic, RT-PCR-confirmed ZIKV infection and early childhood outcomes among their infants. We enrolled pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection in a prospective cohort study, and their infants in a prospective pediatric cohort study. We defined adverse pregnancy and early childhood outcomes based on selected neurologic, ophthalmologic, auditory, musculoskeletal, and anthropometric abnormalities. We used RT-PCR and serologic tests to determine the ZIKV infection status of the child. Between 10 March and 24 November 2016, we enrolled 546 pregnant women with RT-PCR-confirmed ZIKV infection. The overall risk of adverse pregnancy and early childhood outcomes possibly related to in utero ZIKV exposure was 15.7% (95% CI: 12.8–19.0), distributed as follows: 3.6% (95% CI: 2.3–5.6) severe sequelae or fatality; 2.7% (95% CI: 1.6–4.5) major abnormalities; 9.4% (95% CI:7.1–12.2) mild abnormalities. The risk of severe sequelae or fatality was higher when ZIKV infection occurred during the first trimester (7.0%), compared to the second (2.7%) or third trimester (1.4%) (p = 0.02). Among the infants for whom ZIKV infection status could be determined, the vertical transmission rate was 3.0% (5/167) (95% CI: 1.1–7.2). Among pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection, severe or major pregnancy or early childhood outcomes were present in 6.3% of fetuses and infants. Severe outcomes occurred more frequently in fetuses and infants whose mothers had been infected in the first trimester. MDPI 2022-12-10 /pmc/articles/PMC9788325/ /pubmed/36560760 http://dx.doi.org/10.3390/v14122755 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grant, Rebecca
Flechelles, Olivier
Elenga, Narcisse
Tressières, Benoît
Gaete, Stanie
Hebert, Jean-Christophe
Schaub, Bruno
Djossou, Felix
Mallard, Adeline
Delver, Lucetta
Ryan, Catherine
Funk, Anna L.
Cabié, André
Fontanet, Arnaud
Hoen, Bruno
Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study
title Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study
title_full Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study
title_fullStr Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study
title_full_unstemmed Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study
title_short Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study
title_sort consequences of in utero zika virus exposure and adverse pregnancy and early childhood outcomes: a prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788325/
https://www.ncbi.nlm.nih.gov/pubmed/36560760
http://dx.doi.org/10.3390/v14122755
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