Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

Our investigation includes the synthesis of new naphthalene-bis-triazole-bis-quinolin-2(1H)-ones 4a–e and 7a–e via Cu-catalyzed [3 + 2] cycloadditions of 4-azidoquinolin-2(1H)-ones 3a–e with 1,5-/or 1,8-bis(prop-2-yn-1-yloxy)naphthalene (2) or (6). All structures of the obtained products have been c...

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Detalles Bibliográficos
Autores principales: El-Sheref, Essmat M., Ameen, Mohamed A., El-Shaieb, Kamal M., Abdel-Latif, Fathy F., Abdel-naser, Asmaa I., Brown, Alan B., Bräse, Stefan, Fathy, Hazem M., Ahmad, Iqrar, Patel, Harun, Gomaa, Hesham A. M., Youssif, Bahaa G. M., Mohamed, Asmaa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788418/
https://www.ncbi.nlm.nih.gov/pubmed/36557897
http://dx.doi.org/10.3390/molecules27248765

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