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Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering

Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords and medically authorised human analogues made of silk have a long history of use in management. We describe the use of silk in the treatment of eye diseases in this review by looking at the usage of silk f...

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Autores principales: Wani, Shahid Ud Din, Masoodi, Mubashir Hussain, Gautam, Surya Prakash, Shivakumar, H. G., Alshehri, Sultan, Ghoneim, Mohammed M., Alam, Prawez, Shakeel, Faiyaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788421/
https://www.ncbi.nlm.nih.gov/pubmed/36559842
http://dx.doi.org/10.3390/polym14245475
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author Wani, Shahid Ud Din
Masoodi, Mubashir Hussain
Gautam, Surya Prakash
Shivakumar, H. G.
Alshehri, Sultan
Ghoneim, Mohammed M.
Alam, Prawez
Shakeel, Faiyaz
author_facet Wani, Shahid Ud Din
Masoodi, Mubashir Hussain
Gautam, Surya Prakash
Shivakumar, H. G.
Alshehri, Sultan
Ghoneim, Mohammed M.
Alam, Prawez
Shakeel, Faiyaz
author_sort Wani, Shahid Ud Din
collection PubMed
description Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords and medically authorised human analogues made of silk have a long history of use in management. We describe the use of silk in the treatment of eye diseases in this review by looking at the usage of silk fibroin for eye-related drug delivery applications and medication transfer to the eyes. During this ancient art endeavour, a reduced engineering project that employed silk as a platform for medicine delivery or a cell-filled matrix helped reignite interest. With considerable attention, this study explores the present usage of silk in ocular-based drug delivery. This paper also examines emerging developments with the use of silk as a biopolymer for the treatment of eye ailments. As treatment options for glaucoma, diabetic retinopathy, retinitis pigmentosa, and other retinal diseases and degenerations are developed, the trans-scleral route of drug delivery holds great promise for the selective, sustained-release delivery of these novel therapeutic compounds. We should expect a swarm of silk-inspired materials to enter clinical testing and use on the surface as the secrets of silk are unveiled. This article finishes with a discussion on potential silk power, which adds to better ideas and enhanced ocular medicine delivery.
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spelling pubmed-97884212022-12-24 Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering Wani, Shahid Ud Din Masoodi, Mubashir Hussain Gautam, Surya Prakash Shivakumar, H. G. Alshehri, Sultan Ghoneim, Mohammed M. Alam, Prawez Shakeel, Faiyaz Polymers (Basel) Review Silk is a wonderful biopolymer that has a long history of medical applications. Surgical cords and medically authorised human analogues made of silk have a long history of use in management. We describe the use of silk in the treatment of eye diseases in this review by looking at the usage of silk fibroin for eye-related drug delivery applications and medication transfer to the eyes. During this ancient art endeavour, a reduced engineering project that employed silk as a platform for medicine delivery or a cell-filled matrix helped reignite interest. With considerable attention, this study explores the present usage of silk in ocular-based drug delivery. This paper also examines emerging developments with the use of silk as a biopolymer for the treatment of eye ailments. As treatment options for glaucoma, diabetic retinopathy, retinitis pigmentosa, and other retinal diseases and degenerations are developed, the trans-scleral route of drug delivery holds great promise for the selective, sustained-release delivery of these novel therapeutic compounds. We should expect a swarm of silk-inspired materials to enter clinical testing and use on the surface as the secrets of silk are unveiled. This article finishes with a discussion on potential silk power, which adds to better ideas and enhanced ocular medicine delivery. MDPI 2022-12-14 /pmc/articles/PMC9788421/ /pubmed/36559842 http://dx.doi.org/10.3390/polym14245475 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wani, Shahid Ud Din
Masoodi, Mubashir Hussain
Gautam, Surya Prakash
Shivakumar, H. G.
Alshehri, Sultan
Ghoneim, Mohammed M.
Alam, Prawez
Shakeel, Faiyaz
Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
title Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
title_full Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
title_fullStr Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
title_full_unstemmed Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
title_short Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
title_sort promising role of silk-based biomaterials for ocular-based drug delivery and tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788421/
https://www.ncbi.nlm.nih.gov/pubmed/36559842
http://dx.doi.org/10.3390/polym14245475
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