Cargando…
The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with ob...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788441/ https://www.ncbi.nlm.nih.gov/pubmed/36557260 http://dx.doi.org/10.3390/metabo12121221 |
_version_ | 1784858755195731968 |
---|---|
author | Mosca, Antonella Della Volpe, Luca Alisi, Anna Panera, Nadia Maggiore, Giuseppe Vania, Andrea |
author_facet | Mosca, Antonella Della Volpe, Luca Alisi, Anna Panera, Nadia Maggiore, Giuseppe Vania, Andrea |
author_sort | Mosca, Antonella |
collection | PubMed |
description | The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with obesity [12–18 years] were consecutively enrolled between January 2014 and December 2020 and underwent liver biopsy to diagnose MAFLD severity. In all patients GH, IGF1 and Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) were measured. Patients with inflammation and ballooning have significantly lower values of GH and IGF1 than those without (GH: 5.4 vs. 7.5 ng/mL; IGF1 245 vs. 284 ng/mL, p < 0.05). GH and IGF1 were also negatively correlated with fibrosis’ degree (r = −0.51, p = 0.001, and r = −0.45, p = 0.001, respectively). Only GH correlated with TNF-a (r = −0.29, p = 0.04) and lobular inflammation (r = −0.36, p = 0.02). At multivariate regression, both GH and IGF1 values, after adjustment for age, sex and BMI, were negatively associated with HOMA-IR but above all with fibrosis (GH→β = −2.3, p = 0.001, IGF1→β = −2.8, p = 0.001). Even in the pediatric population, a reduction of GH input in the liver directly promotes development of de novo hepatic lipogenesis, steatosis, fibrosis and inflammation. The possible role of recombinant GH administration in adolescents with obesity and severe MAFLD deserves to be studied. |
format | Online Article Text |
id | pubmed-9788441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97884412022-12-24 The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity Mosca, Antonella Della Volpe, Luca Alisi, Anna Panera, Nadia Maggiore, Giuseppe Vania, Andrea Metabolites Article The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with obesity [12–18 years] were consecutively enrolled between January 2014 and December 2020 and underwent liver biopsy to diagnose MAFLD severity. In all patients GH, IGF1 and Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) were measured. Patients with inflammation and ballooning have significantly lower values of GH and IGF1 than those without (GH: 5.4 vs. 7.5 ng/mL; IGF1 245 vs. 284 ng/mL, p < 0.05). GH and IGF1 were also negatively correlated with fibrosis’ degree (r = −0.51, p = 0.001, and r = −0.45, p = 0.001, respectively). Only GH correlated with TNF-a (r = −0.29, p = 0.04) and lobular inflammation (r = −0.36, p = 0.02). At multivariate regression, both GH and IGF1 values, after adjustment for age, sex and BMI, were negatively associated with HOMA-IR but above all with fibrosis (GH→β = −2.3, p = 0.001, IGF1→β = −2.8, p = 0.001). Even in the pediatric population, a reduction of GH input in the liver directly promotes development of de novo hepatic lipogenesis, steatosis, fibrosis and inflammation. The possible role of recombinant GH administration in adolescents with obesity and severe MAFLD deserves to be studied. MDPI 2022-12-05 /pmc/articles/PMC9788441/ /pubmed/36557260 http://dx.doi.org/10.3390/metabo12121221 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mosca, Antonella Della Volpe, Luca Alisi, Anna Panera, Nadia Maggiore, Giuseppe Vania, Andrea The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity |
title | The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity |
title_full | The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity |
title_fullStr | The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity |
title_full_unstemmed | The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity |
title_short | The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity |
title_sort | role of the gh/igf1 axis on the development of mafld in pediatric patients with obesity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788441/ https://www.ncbi.nlm.nih.gov/pubmed/36557260 http://dx.doi.org/10.3390/metabo12121221 |
work_keys_str_mv | AT moscaantonella theroleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT dellavolpeluca theroleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT alisianna theroleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT paneranadia theroleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT maggioregiuseppe theroleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT vaniaandrea theroleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT moscaantonella roleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT dellavolpeluca roleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT alisianna roleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT paneranadia roleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT maggioregiuseppe roleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity AT vaniaandrea roleoftheghigf1axisonthedevelopmentofmafldinpediatricpatientswithobesity |