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The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity

The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with ob...

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Autores principales: Mosca, Antonella, Della Volpe, Luca, Alisi, Anna, Panera, Nadia, Maggiore, Giuseppe, Vania, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788441/
https://www.ncbi.nlm.nih.gov/pubmed/36557260
http://dx.doi.org/10.3390/metabo12121221
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author Mosca, Antonella
Della Volpe, Luca
Alisi, Anna
Panera, Nadia
Maggiore, Giuseppe
Vania, Andrea
author_facet Mosca, Antonella
Della Volpe, Luca
Alisi, Anna
Panera, Nadia
Maggiore, Giuseppe
Vania, Andrea
author_sort Mosca, Antonella
collection PubMed
description The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with obesity [12–18 years] were consecutively enrolled between January 2014 and December 2020 and underwent liver biopsy to diagnose MAFLD severity. In all patients GH, IGF1 and Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) were measured. Patients with inflammation and ballooning have significantly lower values of GH and IGF1 than those without (GH: 5.4 vs. 7.5 ng/mL; IGF1 245 vs. 284 ng/mL, p < 0.05). GH and IGF1 were also negatively correlated with fibrosis’ degree (r = −0.51, p = 0.001, and r = −0.45, p = 0.001, respectively). Only GH correlated with TNF-a (r = −0.29, p = 0.04) and lobular inflammation (r = −0.36, p = 0.02). At multivariate regression, both GH and IGF1 values, after adjustment for age, sex and BMI, were negatively associated with HOMA-IR but above all with fibrosis (GH→β = −2.3, p = 0.001, IGF1→β = −2.8, p = 0.001). Even in the pediatric population, a reduction of GH input in the liver directly promotes development of de novo hepatic lipogenesis, steatosis, fibrosis and inflammation. The possible role of recombinant GH administration in adolescents with obesity and severe MAFLD deserves to be studied.
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spelling pubmed-97884412022-12-24 The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity Mosca, Antonella Della Volpe, Luca Alisi, Anna Panera, Nadia Maggiore, Giuseppe Vania, Andrea Metabolites Article The anomalies of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF1) axis are associated with a higher prevalence of Metabolic Associated Fatty Liver Disease (MAFLD) and with a more rapid progression towards fibrosis, cirrhosis, and end-stage liver disease. A total of 191 adolescents with obesity [12–18 years] were consecutively enrolled between January 2014 and December 2020 and underwent liver biopsy to diagnose MAFLD severity. In all patients GH, IGF1 and Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) were measured. Patients with inflammation and ballooning have significantly lower values of GH and IGF1 than those without (GH: 5.4 vs. 7.5 ng/mL; IGF1 245 vs. 284 ng/mL, p < 0.05). GH and IGF1 were also negatively correlated with fibrosis’ degree (r = −0.51, p = 0.001, and r = −0.45, p = 0.001, respectively). Only GH correlated with TNF-a (r = −0.29, p = 0.04) and lobular inflammation (r = −0.36, p = 0.02). At multivariate regression, both GH and IGF1 values, after adjustment for age, sex and BMI, were negatively associated with HOMA-IR but above all with fibrosis (GH→β = −2.3, p = 0.001, IGF1→β = −2.8, p = 0.001). Even in the pediatric population, a reduction of GH input in the liver directly promotes development of de novo hepatic lipogenesis, steatosis, fibrosis and inflammation. The possible role of recombinant GH administration in adolescents with obesity and severe MAFLD deserves to be studied. MDPI 2022-12-05 /pmc/articles/PMC9788441/ /pubmed/36557260 http://dx.doi.org/10.3390/metabo12121221 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mosca, Antonella
Della Volpe, Luca
Alisi, Anna
Panera, Nadia
Maggiore, Giuseppe
Vania, Andrea
The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
title The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
title_full The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
title_fullStr The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
title_full_unstemmed The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
title_short The Role of the GH/IGF1 Axis on the Development of MAFLD in Pediatric Patients with Obesity
title_sort role of the gh/igf1 axis on the development of mafld in pediatric patients with obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788441/
https://www.ncbi.nlm.nih.gov/pubmed/36557260
http://dx.doi.org/10.3390/metabo12121221
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