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Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts

Ziziphora species (Lamiaceae) have been used in traditional medicine as sedatives, antiseptics, carminatives, or expectorants. Despite their common applications in phytotherapy, there is still lack of evidence about the composition of their extracts and its impact on biological properties of the pla...

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Autores principales: Zhaparkulova, Karlygash, Karaubayeva, Aigerim, Sakipova, Zuriyadda, Biernasiuk, Anna, Gaweł-Bęben, Katarzyna, Laskowski, Tomasz, Kusniyeva, Aliya, Omargali, Azamat, Bekezhanova, Tolkyn, Ibragimova, Liliya, Ibadullayeva, Galiya, Jakiyanov, Amangeldy, Czech, Karolina, Tastambek, Kuanysh, Głowniak, Kazimierz, Malm, Anna, Kukula-Koch, Wirginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788533/
https://www.ncbi.nlm.nih.gov/pubmed/36558125
http://dx.doi.org/10.3390/molecules27248994
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author Zhaparkulova, Karlygash
Karaubayeva, Aigerim
Sakipova, Zuriyadda
Biernasiuk, Anna
Gaweł-Bęben, Katarzyna
Laskowski, Tomasz
Kusniyeva, Aliya
Omargali, Azamat
Bekezhanova, Tolkyn
Ibragimova, Liliya
Ibadullayeva, Galiya
Jakiyanov, Amangeldy
Czech, Karolina
Tastambek, Kuanysh
Głowniak, Kazimierz
Malm, Anna
Kukula-Koch, Wirginia
author_facet Zhaparkulova, Karlygash
Karaubayeva, Aigerim
Sakipova, Zuriyadda
Biernasiuk, Anna
Gaweł-Bęben, Katarzyna
Laskowski, Tomasz
Kusniyeva, Aliya
Omargali, Azamat
Bekezhanova, Tolkyn
Ibragimova, Liliya
Ibadullayeva, Galiya
Jakiyanov, Amangeldy
Czech, Karolina
Tastambek, Kuanysh
Głowniak, Kazimierz
Malm, Anna
Kukula-Koch, Wirginia
author_sort Zhaparkulova, Karlygash
collection PubMed
description Ziziphora species (Lamiaceae) have been used in traditional medicine as sedatives, antiseptics, carminatives, or expectorants. Despite their common applications in phytotherapy, there is still lack of evidence about the composition of their extracts and its impact on biological properties of the plants. The aim of this study was to evaluate the content of Ziziphora bungeana, a less studied species growing in Kazakhstan, using HPLC-ESI-QTOF-MS/MS instrumentation and to determine its antimicrobial, antioxidant, and cytotoxic activity together with inhibitory properties against tyrosinase and toxicity in erythrocyte lysis assay. Extracts from Z. bungeana were found to be sources of flavonoids, phenolic acids, organic acids, and terpenes that determined their antiradical activity. The minimum inhibitory concentrations of extracts were lower for Gram-positive bacteria (1.25–10 mg/mL) than for Gram-negative bacteria and fungi (5–20 mg/mL). The EC(50) value calculated for antiradical activity ranged between 15.00 ± 1.06 µg/mL and 13.21 ± 3.24 µg/mL for ABTS and DPPH assays, respectively. Z. bungeana extracts were found to decrease the activity of tyrosinase by 50% (at 200 µg/mL) similarly to kojic acid and were slightly cytotoxic for human melanoma A375 cell line (at 200 µg/mL) with no effect on HaCaT keratinocytes. In the end, Z. bungeana did not reveal toxic effects in hemolytic assay as compared to the positive control Triton X-100. The performed tests show potential application of the plant in the treatment of infectious diseases, disorders caused by free radicals, and skin problems.
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spelling pubmed-97885332022-12-24 Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts Zhaparkulova, Karlygash Karaubayeva, Aigerim Sakipova, Zuriyadda Biernasiuk, Anna Gaweł-Bęben, Katarzyna Laskowski, Tomasz Kusniyeva, Aliya Omargali, Azamat Bekezhanova, Tolkyn Ibragimova, Liliya Ibadullayeva, Galiya Jakiyanov, Amangeldy Czech, Karolina Tastambek, Kuanysh Głowniak, Kazimierz Malm, Anna Kukula-Koch, Wirginia Molecules Article Ziziphora species (Lamiaceae) have been used in traditional medicine as sedatives, antiseptics, carminatives, or expectorants. Despite their common applications in phytotherapy, there is still lack of evidence about the composition of their extracts and its impact on biological properties of the plants. The aim of this study was to evaluate the content of Ziziphora bungeana, a less studied species growing in Kazakhstan, using HPLC-ESI-QTOF-MS/MS instrumentation and to determine its antimicrobial, antioxidant, and cytotoxic activity together with inhibitory properties against tyrosinase and toxicity in erythrocyte lysis assay. Extracts from Z. bungeana were found to be sources of flavonoids, phenolic acids, organic acids, and terpenes that determined their antiradical activity. The minimum inhibitory concentrations of extracts were lower for Gram-positive bacteria (1.25–10 mg/mL) than for Gram-negative bacteria and fungi (5–20 mg/mL). The EC(50) value calculated for antiradical activity ranged between 15.00 ± 1.06 µg/mL and 13.21 ± 3.24 µg/mL for ABTS and DPPH assays, respectively. Z. bungeana extracts were found to decrease the activity of tyrosinase by 50% (at 200 µg/mL) similarly to kojic acid and were slightly cytotoxic for human melanoma A375 cell line (at 200 µg/mL) with no effect on HaCaT keratinocytes. In the end, Z. bungeana did not reveal toxic effects in hemolytic assay as compared to the positive control Triton X-100. The performed tests show potential application of the plant in the treatment of infectious diseases, disorders caused by free radicals, and skin problems. MDPI 2022-12-16 /pmc/articles/PMC9788533/ /pubmed/36558125 http://dx.doi.org/10.3390/molecules27248994 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhaparkulova, Karlygash
Karaubayeva, Aigerim
Sakipova, Zuriyadda
Biernasiuk, Anna
Gaweł-Bęben, Katarzyna
Laskowski, Tomasz
Kusniyeva, Aliya
Omargali, Azamat
Bekezhanova, Tolkyn
Ibragimova, Liliya
Ibadullayeva, Galiya
Jakiyanov, Amangeldy
Czech, Karolina
Tastambek, Kuanysh
Głowniak, Kazimierz
Malm, Anna
Kukula-Koch, Wirginia
Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts
title Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts
title_full Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts
title_fullStr Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts
title_full_unstemmed Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts
title_short Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts
title_sort multidirectional characterization of phytochemical profile and health-promoting effects of ziziphora bungeana juz. extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788533/
https://www.ncbi.nlm.nih.gov/pubmed/36558125
http://dx.doi.org/10.3390/molecules27248994
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