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Doxorubicin-Induced Platelet Activation and Clearance Relieved by Salvianolic Acid Compound: Novel Mechanism and Potential Therapy for Chemotherapy-Associated Thrombosis and Thrombocytopenia

Doxorubicin (Dox) is a widely utilized chemotherapeutic; however, it carries side effects, including drug-induced immune thrombocytopenia (DITP) and increased risk of venous thromboembolism (VTE). Currently, the mechanisms for Dox-associated DITP and VTE are poorly understood, and an effective inhib...

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Detalles Bibliográficos
Autores principales: Ma, Wenjing, Rousseau, Zackary, Slavkovic, Sladjana, Shen, Chuanbin, Yousef, George M., Ni, Heyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788583/
https://www.ncbi.nlm.nih.gov/pubmed/36558895
http://dx.doi.org/10.3390/ph15121444