Cargando…

Diallyl Disulfide Induces Chemosensitization to Sorafenib, Autophagy, and Cell Cycle Arrest and Inhibits Invasion in Hepatocellular Carcinoma

Hepatocellular carcinoma is the seventh most common type of cancer in the world, with limited treatment options. A promising strategy to treat cancer is to associate chemotherapeutics and plant bioactive compounds. Here, we examined whether diallyl disulfide (DADS; 50–200 μM) and sorafenib (SORA; 8...

Descripción completa

Detalles Bibliográficos
Autores principales:	Machado, Ana Rita Thomazela, Tuttis, Katiuska, Santos, Patrick Wellington da Silva, Aissa, Alexandre Ferro, Antunes, Lusânia Maria Greggi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788602/ https://www.ncbi.nlm.nih.gov/pubmed/36559076 http://dx.doi.org/10.3390/pharmaceutics14122582

Ejemplares similares

Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells
por: Tuttis, Katiuska, et al.
Publicado: (2023)

Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines
por: Hernandes, Lívia Cristina, et al.
Publicado: (2020)

BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells
por: Machado, Ana Rita Thomazela, et al.
Publicado: (2019)

Exploring the role and mechanisms of diallyl trisulfide and diallyl disulfide in chronic constriction-induced neuropathic pain in rats
por: Wang, Gang, et al.
Publicado: (2020)

Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer
por: Malla, RamaRao, et al.
Publicado: (2022)

Diallyl disulfide attenuates acetaminophen-induced renal injury in rats
por: Shin, Jin-Young, et al.
Publicado: (2016)

Fatty liver and alteration of the gut microbiome induced by diallyl disulfide
por: Yang, Yanhong, et al.
Publicado: (2019)

Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential
por: Mitra, Saikat, et al.
Publicado: (2022)

Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line
por: Lee, Jeong-Eun, et al.
Publicado: (2011)

Protective effect of diallyl disulfide on cyclophosphamide-induced testicular toxicity in rats
por: Kim, Sung-Hwan, et al.
Publicado: (2013)

Garlic Volatile Diallyl Disulfide Induced Cucumber Resistance to Downy Mildew
por: Yang, Fan, et al.
Publicado: (2021)

Ameliorative Role of Diallyl Disulfide Against Glycerol-induced Nephrotoxicity in Rats
por: Sharma, Ashwani Kumar, et al.
Publicado: (2021)

The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death
por: Ribeiro, Diego Luis, et al.
Publicado: (2022)

Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom
por: Oliveira, Isadora Sousa de, et al.
Publicado: (2018)

Transcriptomic insights into the allelopathic effects of the garlic allelochemical diallyl disulfide on tomato roots
por: Cheng, Fang, et al.
Publicado: (2016)

Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer
por: Xiong, Ting, et al.
Publicado: (2018)

Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines
por: Choromanska, Anna, et al.
Publicado: (2020)

Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation
por: Nakajima, Tetsuo, et al.
Publicado: (2019)

Corrigendum: Transcriptomic insights into the allelopathic effects of the garlic allelochemical diallyl disulfide on tomato roots
por: Cheng, Fang, et al.
Publicado: (2017)

Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound
por: Song, Xiuxiu, et al.
Publicado: (2021)

The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain
por: Bai, Xue, et al.
Publicado: (2021)

Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway
por: Yue, Ziqi, et al.
Publicado: (2019)

Involvement of calreticulin in cell proliferation, invasion and differentiation in diallyl disulfide-treated HL-60 cells
por: Yi, Lan, et al.
Publicado: (2016)

The Effect of Garlic Derivatives (S-Allylmercaptocysteine, Diallyl Disulfide, and S-Allylcysteine) on Gentamicin Induced Ototoxicity: An Experimental Study
por: Uzun, Lokman, et al.
Publicado: (2016)

The Effect of Liposomal Diallyl Disulfide and Oxaliplatin on Proliferation of Colorectal Cancer Cells: In Vitro and In Silico Analysis
por: Alrumaihi, Faris, et al.
Publicado: (2022)

Cytotoxic Effects of Nanoliposomal Cisplatin and Diallyl Disulfide on Breast Cancer and Lung Cancer Cell Lines
por: Gunasekaran, Kaavya, et al.
Publicado: (2023)

Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl(+) cells
por: Burin, Sandra Mara, et al.
Publicado: (2020)

Subcellular localization of DJ-1 in human HL-60 leukemia cells in response to diallyl disulfide treatment
por: Li, Qingye, et al.
Publicado: (2016)

Prophylaxis of Diallyl Disulfide on Skin Carcinogenic Model via p21-dependent Nrf2 stabilization
por: Shan, Yunlong, et al.
Publicado: (2016)

Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition
por: Xia, Longzheng, et al.
Publicado: (2019)

Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer
por: Su, Bo, et al.
Publicado: (2016)

Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice
por: Zhang, Hongxing, et al.
Publicado: (2020)

Development of a Silicone-Based Polymer Matrix as a Suitable Transdermal Therapeutic System for Diallyl Disulfide
por: László, Szabolcs, et al.
Publicado: (2022)

Diallyl disulfide down‐regulates calreticulin and promotes C/EBPα expression in differentiation of human leukaemia cells
por: Sun, Jing, et al.
Publicado: (2018)

Diallyl Disulfide From Garlic Oil Inhibits Pseudomonas aeruginosa Quorum Sensing Systems and Corresponding Virulence Factors
por: Li, Wen-Ru, et al.
Publicado: (2019)

The Disulfide Stress Response and Protein S-thioallylation Caused by Allicin and Diallyl Polysulfanes in Bacillus subtilis as Revealed by Transcriptomics and Proteomics
por: Chi, Bui Khanh, et al.
Publicado: (2019)

Preventive Effect of Garlic Oil and Its Organosulfur Component Diallyl-Disulfide on Cigarette Smoke-Induced Airway Inflammation in Mice
por: Ko, Je-Won, et al.
Publicado: (2018)

Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis via NF-κB–NFATc1 signal pathway
por: Yang, Jing, et al.
Publicado: (2019)

Measurement of diallyl disulfide and allyl methyl sulfide emanating from human skin surface and influence of ingestion of grilled garlic
por: Sato, Shodai, et al.
Publicado: (2020)

The Garlic Allelochemical Diallyl Disulfide Affects Tomato Root Growth by Influencing Cell Division, Phytohormone Balance and Expansin Gene Expression
por: Cheng, Fang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7dnpq5ri4a65b13pl3ln0vn9lj