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A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT
Background Rosai-Dorfman disease (RDD), the massive lymphadenopathy characterized by the proliferation of sinus histiocytosis, is a relatively idiopathic benign disease with unknown etiology. We reported a rare case of thymic RDD detected by (18)F-FDG PET/CT. A 23-year-old man with right-sided chest...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788635/ https://www.ncbi.nlm.nih.gov/pubmed/36548529 http://dx.doi.org/10.3390/tomography8060237 |
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author | Jia, Tongtong Zhang, Bin Zhang, Xiaoyi Xu, Xin Sang, Shibiao Deng, Shengming |
author_facet | Jia, Tongtong Zhang, Bin Zhang, Xiaoyi Xu, Xin Sang, Shibiao Deng, Shengming |
author_sort | Jia, Tongtong |
collection | PubMed |
description | Background Rosai-Dorfman disease (RDD), the massive lymphadenopathy characterized by the proliferation of sinus histiocytosis, is a relatively idiopathic benign disease with unknown etiology. We reported a rare case of thymic RDD detected by (18)F-FDG PET/CT. A 23-year-old man with right-sided chest pain underwent (18)F-FDG PET/CT scan, showing increased (18)F-FDG uptake in an anterior mediastinal mass corresponding to a thymic lesion at an enhanced CT scan. The patient was referred to surgery with the clinical suspicion of thymic malignancy. The histological examination and immunohistochemical results confirmed RDD. Conclusions This was the first case report of RDD isolated to the thymus and initially presented with chest pain. Moreover, there was no characteristic painless neck lymphadenopathy at any stage of the disease course. Thus, for young patients with thymus mass, RDD should be considered a rare but possible diagnosis. |
format | Online Article Text |
id | pubmed-9788635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97886352022-12-24 A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT Jia, Tongtong Zhang, Bin Zhang, Xiaoyi Xu, Xin Sang, Shibiao Deng, Shengming Tomography Case Report Background Rosai-Dorfman disease (RDD), the massive lymphadenopathy characterized by the proliferation of sinus histiocytosis, is a relatively idiopathic benign disease with unknown etiology. We reported a rare case of thymic RDD detected by (18)F-FDG PET/CT. A 23-year-old man with right-sided chest pain underwent (18)F-FDG PET/CT scan, showing increased (18)F-FDG uptake in an anterior mediastinal mass corresponding to a thymic lesion at an enhanced CT scan. The patient was referred to surgery with the clinical suspicion of thymic malignancy. The histological examination and immunohistochemical results confirmed RDD. Conclusions This was the first case report of RDD isolated to the thymus and initially presented with chest pain. Moreover, there was no characteristic painless neck lymphadenopathy at any stage of the disease course. Thus, for young patients with thymus mass, RDD should be considered a rare but possible diagnosis. MDPI 2022-11-28 /pmc/articles/PMC9788635/ /pubmed/36548529 http://dx.doi.org/10.3390/tomography8060237 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Jia, Tongtong Zhang, Bin Zhang, Xiaoyi Xu, Xin Sang, Shibiao Deng, Shengming A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT |
title | A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT |
title_full | A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT |
title_fullStr | A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT |
title_full_unstemmed | A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT |
title_short | A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on (18)F-FDG PET/CT |
title_sort | rare case of thymic rosai-dorfman disease mimicking malignancy on (18)f-fdg pet/ct |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788635/ https://www.ncbi.nlm.nih.gov/pubmed/36548529 http://dx.doi.org/10.3390/tomography8060237 |
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