Cargando…

Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors

Chimeric antigen receptor (CAR)-T cells have demonstrated significant improvements in the treatment of refractory B-cell malignancies that previously showed limited survival. In contrast, early-phase clinical studies targeting solid tumors have been disappointing. This may be due to both a lack of s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laurent, Pierre-Antoine, Morel, Daphne, Meziani, Lydia, Depil, Stephane, Deutsch, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788698/ https://www.ncbi.nlm.nih.gov/pubmed/36567802 http://dx.doi.org/10.1080/2162402X.2022.2158013

Ejemplares similares

Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation
por: Meziani, Lydia, et al.
Publicado: (2023)

TCR-engineered T cell therapy in solid tumors: State of the art and perspectives
por: Baulu, Estelle, et al.
Publicado: (2023)

KRAS(G12C) inhibition using MRTX1257: a novel radio-sensitizing partner
por: Laurent, Pierre-Antoine, et al.
Publicado: (2023)

Radiotherapy–immunotherapy combinations – perspectives and challenges
por: Mondini, Michele, et al.
Publicado: (2020)

TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy
por: Hamon, Pauline, et al.
Publicado: (2022)

Macrophages in radiation injury: a new therapeutic target
por: Meziani, Lydia, et al.
Publicado: (2018)

Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models
por: Tran Chau, Vanessa, et al.
Publicado: (2020)

Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia
por: Meziani, Lydia, et al.
Publicado: (2021)

Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat
por: Rivera, Sofia, et al.
Publicado: (2017)

Proton Radiotherapy for Solid Tumors of Childhood
por: Cotter, Shane E., et al.
Publicado: (2012)

Combination of CAR‑T cell therapy and radiotherapy: Opportunities and challenges in solid tumors (Review)
por: Zhong, Liqiang, et al.
Publicado: (2023)

Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy
por: Smith, Clayton A., et al.
Publicado: (2016)

Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution
por: de Pinho Pessoa, Flávia Melo Cunha, et al.
Publicado: (2022)

Hypoxia in Solid Tumors: How Low Oxygenation Impacts the “Six Rs” of Radiotherapy
por: Rakotomalala, Andria, et al.
Publicado: (2021)

Integrating [(18)F]-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography with Radiation Therapy and Immunomodulation in Precision Therapy for Solid Tumors
por: Prendergast, Conor M., et al.
Publicado: (2023)

Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors
por: Peyraud, Florent, et al.
Publicado: (2020)

Preclinical Study of Plasmodium Immunotherapy Combined with Radiotherapy for Solid Tumors
por: Tao, Zhu, et al.
Publicado: (2022)

Cancer vaccines: what’s next?
por: Depil, Stéphane, et al.
Publicado: (2019)

Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers
por: Alcazer, Vincent, et al.
Publicado: (2020)

Theranostic Nanoseeds for Efficacious Internal Radiation Therapy of Unresectable Solid Tumors
por: Moeendarbari, Sina, et al.
Publicado: (2016)

A phase 1 dose-escalation study of the oral histone deacetylase inhibitor abexinostat in combination with standard hypofractionated radiotherapy in advanced solid tumors
por: Deutsch, Eric, et al.
Publicado: (2016)

Efficacy and safety of PD1/PDL1 inhibitors combined with radiotherapy and anti-angiogenic therapy for solid tumors: A systematic review and meta-analysis
por: Xian, Feng, et al.
Publicado: (2023)

Treatment of Nasopharyngeal Carcinoma Cells with the Histone-Deacetylase Inhibitor Abexinostat: Cooperative Effects with Cis-platin and Radiotherapy on Patient-Derived Xenografts
por: Gressette, Mélanie, et al.
Publicado: (2014)

Toll-Like Receptors and the Response to Radiotherapy in Solid Tumors: Challenges and Opportunities
por: Haroun, Ryma, et al.
Publicado: (2023)

COVID-19-Associated Pneumonia: Radiobiological Insights
por: François, Sabine, et al.
Publicado: (2021)

Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?
por: Martin-Romano, Patricia, et al.
Publicado: (2021)

Cold Tumors: A Therapeutic Challenge for Immunotherapy
por: Bonaventura, Paola, et al.
Publicado: (2019)

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies
por: Genard, Géraldine, et al.
Publicado: (2017)

Challenges of evaluating immunotherapy efficacy in solid tumors
por: Bai, Rilan, et al.
Publicado: (2019)

Strategies to Increase Drug Penetration in Solid Tumors
por: Choi, Il-Kyu, et al.
Publicado: (2013)

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors
por: Ghahri-Saremi, Navid, et al.
Publicado: (2021)

Enhanced Sensitivity to Low Dose Irradiation of ApoE−/− Mice Mediated by Early Pro-Inflammatory Profile and Delayed Activation of the TGFβ1 Cascade Involved in Fibrogenesis
por: Monceau, Virginie, et al.
Publicado: (2013)

From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors
por: Kryza, David, et al.
Publicado: (2023)

Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors
por: Leung, Eric, et al.
Publicado: (2017)

Solid Tumor Differentiation Therapy – Is It Possible?
por: Dela Cruz, Filemon, et al.
Publicado: (2012)

Onivyde for the therapy of multiple solid tumors
por: Zhang, Haijun
Publicado: (2016)

Hypofractionated Low-Dose Radiotherapy Combined with Immune Checkpoint Inhibition in Metastatic Solid Tumors
por: Li, Dongqing, et al.
Publicado: (2021)

Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy
por: Cruz, Esteban, et al.
Publicado: (2019)

The synergistic efficacy of hydroxychloroquine with methotrexate is accompanied by increased erythrocyte mean corpuscular volume
por: Shipa, Muhammad Ruhul Amin, et al.
Publicado: (2021)

Oral insulin delivery by means of solid lipid nanoparticles
por: Sarmento, Bruno, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_qhdlsdkhsmqtg9g8uoal0jut8o