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Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China

Enterovirus 76 (EV-A76) is a serotype of enterovirus A and has been rarely reported. In this paper, we present the genetic characteristics of 15 EV-A76 isolates reported to circulate in the Xinjiang Uighur autonomous region of China in 2011. Sequence analysis revealed that all Chinese EV-A76 isolate...

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Autores principales: Li, Xiaolei, Lu, Huanhuan, Sun, Qiang, Zheng, Peng, Zhang, Bo, Cui, Hui, Tang, Haishu, Zhao, Hehe, Liu, Ying, Jiang, Jie, Xiao, Jinbo, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788713/
https://www.ncbi.nlm.nih.gov/pubmed/36394478
http://dx.doi.org/10.1080/22221751.2022.2149350
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author Li, Xiaolei
Lu, Huanhuan
Sun, Qiang
Zheng, Peng
Zhang, Bo
Cui, Hui
Tang, Haishu
Zhao, Hehe
Liu, Ying
Jiang, Jie
Xiao, Jinbo
Zhang, Yong
author_facet Li, Xiaolei
Lu, Huanhuan
Sun, Qiang
Zheng, Peng
Zhang, Bo
Cui, Hui
Tang, Haishu
Zhao, Hehe
Liu, Ying
Jiang, Jie
Xiao, Jinbo
Zhang, Yong
author_sort Li, Xiaolei
collection PubMed
description Enterovirus 76 (EV-A76) is a serotype of enterovirus A and has been rarely reported. In this paper, we present the genetic characteristics of 15 EV-A76 isolates reported to circulate in the Xinjiang Uighur autonomous region of China in 2011. Sequence analysis revealed that all Chinese EV-A76 isolates had high similarity (> 98.3%) in the VP1 region, and five Chinese EV-A76 isolates were selected for whole genome sequencing based on VP1 nucleotide divergence. Similarity plots and boot-scanning analyses revealed frequent intertypic recombination in the nonstructural region of the EV-A76 isolate, as found with the EV-A89 donor sequence (also isolated in Xinjiang). The breakpoint of recombination is around nucleotide 3960, and the recombinant fragments covered part 2C and all P3 regions. This study increases publicly available EV-A76 nucleotide sequence and further our understanding EV-A76 molecular epidemiology.
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spelling pubmed-97887132022-12-24 Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China Li, Xiaolei Lu, Huanhuan Sun, Qiang Zheng, Peng Zhang, Bo Cui, Hui Tang, Haishu Zhao, Hehe Liu, Ying Jiang, Jie Xiao, Jinbo Zhang, Yong Emerg Microbes Infect Letter Enterovirus 76 (EV-A76) is a serotype of enterovirus A and has been rarely reported. In this paper, we present the genetic characteristics of 15 EV-A76 isolates reported to circulate in the Xinjiang Uighur autonomous region of China in 2011. Sequence analysis revealed that all Chinese EV-A76 isolates had high similarity (> 98.3%) in the VP1 region, and five Chinese EV-A76 isolates were selected for whole genome sequencing based on VP1 nucleotide divergence. Similarity plots and boot-scanning analyses revealed frequent intertypic recombination in the nonstructural region of the EV-A76 isolate, as found with the EV-A89 donor sequence (also isolated in Xinjiang). The breakpoint of recombination is around nucleotide 3960, and the recombinant fragments covered part 2C and all P3 regions. This study increases publicly available EV-A76 nucleotide sequence and further our understanding EV-A76 molecular epidemiology. Taylor & Francis 2022-12-20 /pmc/articles/PMC9788713/ /pubmed/36394478 http://dx.doi.org/10.1080/22221751.2022.2149350 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter
Li, Xiaolei
Lu, Huanhuan
Sun, Qiang
Zheng, Peng
Zhang, Bo
Cui, Hui
Tang, Haishu
Zhao, Hehe
Liu, Ying
Jiang, Jie
Xiao, Jinbo
Zhang, Yong
Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China
title Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China
title_full Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China
title_fullStr Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China
title_full_unstemmed Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China
title_short Transmission of recombinant enterovirus A76 (EV-A76) in Xinjiang Uighur autonomous region of China
title_sort transmission of recombinant enterovirus a76 (ev-a76) in xinjiang uighur autonomous region of china
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788713/
https://www.ncbi.nlm.nih.gov/pubmed/36394478
http://dx.doi.org/10.1080/22221751.2022.2149350
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